The Structure and Classification of Botulinum Toxins
Dong, Min and Stenmark, Pål LU
(2021)
In Handbook of experimental pharmacology
263.
p.11-33
- Abstract
Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to... (More)
Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.
(Less)
- author
- Dong, Min
and Stenmark, Pål
LU
- organization
- publishing date
- 2021
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Botulinum Toxin Therapy
- series title
- Handbook of experimental pharmacology
- editor
- Whitcup, Scott M. and Hallett, Mark
- volume
- 263
- pages
- 23 pages
- publisher
- Springer Nature
- external identifiers
-
- scopus:85099428704
- pmid:31792680
- ISSN
- 0171-2004
- ISBN
- 978-3-030-66305-6
- DOI
- 10.1007/164_2019_342
- language
- English
- LU publication?
- yes
- id
- b894e3fa-222e-40c0-8069-026751647e6d
- date added to LUP
- 2019-12-11 12:46:16
- date last changed
- 2024-04-17 01:10:19
@inbook{b894e3fa-222e-40c0-8069-026751647e6d,
abstract = {{<p>Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.</p>}},
author = {{Dong, Min and Stenmark, Pål}},
booktitle = {{Botulinum Toxin Therapy}},
editor = {{Whitcup, Scott M. and Hallett, Mark}},
isbn = {{978-3-030-66305-6}},
issn = {{0171-2004}},
language = {{eng}},
pages = {{11--33}},
publisher = {{Springer Nature}},
series = {{Handbook of experimental pharmacology}},
title = {{The Structure and Classification of Botulinum Toxins}},
url = {{http://dx.doi.org/10.1007/164_2019_342}},
doi = {{10.1007/164_2019_342}},
volume = {{263}},
year = {{2021}},
}