Type 1 diabetes, cognitive ability and incidence of cardiovascular disease and death over 60 years of follow-up time in men
(2022) In Diabetic Medicine: A journal of the British Diabetic Association 39(8).- Abstract
AIMS: There are few cohorts of type 1 diabetes that follow individuals over more than half a century in terms of health outcomes. The aim of this study was to examine associations between type 1 diabetes, diagnosed before age 18, and long-term morbidity and mortality, and to investigate whether cognitive ability plays a role in long-term morbidity and mortality risk.
METHODS: In a Swedish cohort, 120 men with type 1 diabetes and 469 without type 1 diabetes were followed between 18 and 77 years of age as regards morbidity and mortality outcomes, and impact of cognitive ability at military conscription for the outcomes. In Cox regression analyses and Kaplan-Meier analyses with log-rank tests, associations between diabetes and... (More)
AIMS: There are few cohorts of type 1 diabetes that follow individuals over more than half a century in terms of health outcomes. The aim of this study was to examine associations between type 1 diabetes, diagnosed before age 18, and long-term morbidity and mortality, and to investigate whether cognitive ability plays a role in long-term morbidity and mortality risk.
METHODS: In a Swedish cohort, 120 men with type 1 diabetes and 469 without type 1 diabetes were followed between 18 and 77 years of age as regards morbidity and mortality outcomes, and impact of cognitive ability at military conscription for the outcomes. In Cox regression analyses and Kaplan-Meier analyses with log-rank tests, associations between diabetes and cognitive ability respectively, and outcomes (mortality, cardiovascular morbidity and diabetes complications) were investigated.
RESULTS: Men with type 1 diabetes suffered from dramatically higher mortality (HR 4.62, 95% CI: 3.56-5.60), cardiovascular mortality (HR 5.60, 95% CI: 3.27-9.57), and cardiovascular events (HR 3.97, 95% CI: 2.79-5.64) compared to men without diabetes. Higher cognitive ability at military conscription was associated with lower mortality in men without diabetes, but was not associated with any outcome in men with diabetes.
CONCLUSIONS: In this historical cohort study with 60 years of follow-up time and a less effective treatment of diabetes than today, mortality rates and cardiovascular outcomes were high for men with type 1 diabetes. Morbidity or mortality did not differ between those that had low to normal or high cognitive ability among men with type 1 diabetes.
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- author
- Dybjer, Elin LU ; Dahl Aslan, Anna K ; Engström, Gunnar LU ; Nilsson, Erik D LU ; Nägga, Katarina LU ; Nilsson, Peter M LU and Hassing, Linda B
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetic Medicine: A journal of the British Diabetic Association
- volume
- 39
- issue
- 8
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:35129223
- scopus:85124557078
- ISSN
- 1464-5491
- DOI
- 10.1111/dme.14806
- project
- Diabetes and glucometabolic markers related to cognitive outcomes in the population. Epidemiological and mechanistic aspects.
- language
- English
- LU publication?
- yes
- additional info
- © 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
- id
- ba8cd092-d611-493f-a356-4d03e81d3d30
- date added to LUP
- 2022-02-22 09:46:31
- date last changed
- 2024-06-20 01:45:47
@article{ba8cd092-d611-493f-a356-4d03e81d3d30,
abstract = {{<p>AIMS: There are few cohorts of type 1 diabetes that follow individuals over more than half a century in terms of health outcomes. The aim of this study was to examine associations between type 1 diabetes, diagnosed before age 18, and long-term morbidity and mortality, and to investigate whether cognitive ability plays a role in long-term morbidity and mortality risk.</p><p>METHODS: In a Swedish cohort, 120 men with type 1 diabetes and 469 without type 1 diabetes were followed between 18 and 77 years of age as regards morbidity and mortality outcomes, and impact of cognitive ability at military conscription for the outcomes. In Cox regression analyses and Kaplan-Meier analyses with log-rank tests, associations between diabetes and cognitive ability respectively, and outcomes (mortality, cardiovascular morbidity and diabetes complications) were investigated.</p><p>RESULTS: Men with type 1 diabetes suffered from dramatically higher mortality (HR 4.62, 95% CI: 3.56-5.60), cardiovascular mortality (HR 5.60, 95% CI: 3.27-9.57), and cardiovascular events (HR 3.97, 95% CI: 2.79-5.64) compared to men without diabetes. Higher cognitive ability at military conscription was associated with lower mortality in men without diabetes, but was not associated with any outcome in men with diabetes.</p><p>CONCLUSIONS: In this historical cohort study with 60 years of follow-up time and a less effective treatment of diabetes than today, mortality rates and cardiovascular outcomes were high for men with type 1 diabetes. Morbidity or mortality did not differ between those that had low to normal or high cognitive ability among men with type 1 diabetes.</p>}},
author = {{Dybjer, Elin and Dahl Aslan, Anna K and Engström, Gunnar and Nilsson, Erik D and Nägga, Katarina and Nilsson, Peter M and Hassing, Linda B}},
issn = {{1464-5491}},
language = {{eng}},
number = {{8}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine: A journal of the British Diabetic Association}},
title = {{Type 1 diabetes, cognitive ability and incidence of cardiovascular disease and death over 60 years of follow-up time in men}},
url = {{http://dx.doi.org/10.1111/dme.14806}},
doi = {{10.1111/dme.14806}},
volume = {{39}},
year = {{2022}},
}