Effects of calcium antagonists on myogenic and neurogenic control of resistance and capacitance vessels in cat skeletal muscle
(1988) In Journal of Cardiovascular Pharmacology 12(4). p.22-413- Abstract
The effects of five different calcium antagonists (diltiazem, felodipine, nifedipine, nimodipine, and verapamil) on cat skeletal muscle resistance and capacitance vessels were studied in a whole organ preparation. These calcium antagonists seemed to have the similar qualitative effects on these vascular functions. Calcium antagonists were found to be potent inhibitors of myogenic vascular reactivity (here defined as the maximal increase in flow resistance evoked by a sudden rise of transmural pressure). Basal vascular tone and vascular tone induced by low frequency stimulation of sympathetic nerves were both less sensitive to these drugs than vascular tone induced by myogenic vascular reactivity. Sympathetically mediated vascular tone... (More)
The effects of five different calcium antagonists (diltiazem, felodipine, nifedipine, nimodipine, and verapamil) on cat skeletal muscle resistance and capacitance vessels were studied in a whole organ preparation. These calcium antagonists seemed to have the similar qualitative effects on these vascular functions. Calcium antagonists were found to be potent inhibitors of myogenic vascular reactivity (here defined as the maximal increase in flow resistance evoked by a sudden rise of transmural pressure). Basal vascular tone and vascular tone induced by low frequency stimulation of sympathetic nerves were both less sensitive to these drugs than vascular tone induced by myogenic vascular reactivity. Sympathetically mediated vascular tone at high stimulation frequencies seemed to be least sensitive. Further, resistance vessels were much more sensitive to these drugs than capacitance vessels. Finally, basal tone in the large bore arterioles were more sensitive than in the small bore arterioles, a surprising finding which was interpreted with the aid of computer simulations using a mathematical model of local vascular control in cat skeletal muscle. The model suggested that this difference could be due to a delicate interaction between myogenic vascular reactivity and metabolic vascular control. It is suggested that the inhibition of myogenic vascular reactivity is a factor contributing to the edema formation of calcium antagonists.
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- author
- Gustafsson, D ; Grände, P O LU ; Borgström, P and Lindberg, L LU
- organization
- publishing date
- 1988-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Blood Vessels, Calcium Channel Blockers, Cats, Female, In Vitro Techniques, Male, Muscle Tonus, Muscle, Smooth, Vascular, Regional Blood Flow, Vascular Resistance, Journal Article, Research Support, Non-U.S. Gov't
- in
- Journal of Cardiovascular Pharmacology
- volume
- 12
- issue
- 4
- pages
- 10 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:2465441
- scopus:0023750420
- ISSN
- 0160-2446
- language
- English
- LU publication?
- yes
- id
- ba987763-44bc-4fbe-921d-483b2e62e5e7
- alternative location
- https://journals.lww.com/cardiovascularpharm/Abstract/1988/10000/Effects_of_Calcium_Antagonists_on_Myogenic_and.6.aspx
- date added to LUP
- 2018-04-25 13:35:32
- date last changed
- 2024-01-14 19:17:50
@article{ba987763-44bc-4fbe-921d-483b2e62e5e7,
abstract = {{<p>The effects of five different calcium antagonists (diltiazem, felodipine, nifedipine, nimodipine, and verapamil) on cat skeletal muscle resistance and capacitance vessels were studied in a whole organ preparation. These calcium antagonists seemed to have the similar qualitative effects on these vascular functions. Calcium antagonists were found to be potent inhibitors of myogenic vascular reactivity (here defined as the maximal increase in flow resistance evoked by a sudden rise of transmural pressure). Basal vascular tone and vascular tone induced by low frequency stimulation of sympathetic nerves were both less sensitive to these drugs than vascular tone induced by myogenic vascular reactivity. Sympathetically mediated vascular tone at high stimulation frequencies seemed to be least sensitive. Further, resistance vessels were much more sensitive to these drugs than capacitance vessels. Finally, basal tone in the large bore arterioles were more sensitive than in the small bore arterioles, a surprising finding which was interpreted with the aid of computer simulations using a mathematical model of local vascular control in cat skeletal muscle. The model suggested that this difference could be due to a delicate interaction between myogenic vascular reactivity and metabolic vascular control. It is suggested that the inhibition of myogenic vascular reactivity is a factor contributing to the edema formation of calcium antagonists.</p>}},
author = {{Gustafsson, D and Grände, P O and Borgström, P and Lindberg, L}},
issn = {{0160-2446}},
keywords = {{Animals; Blood Vessels; Calcium Channel Blockers; Cats; Female; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Regional Blood Flow; Vascular Resistance; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{4}},
pages = {{22--413}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Cardiovascular Pharmacology}},
title = {{Effects of calcium antagonists on myogenic and neurogenic control of resistance and capacitance vessels in cat skeletal muscle}},
url = {{https://journals.lww.com/cardiovascularpharm/Abstract/1988/10000/Effects_of_Calcium_Antagonists_on_Myogenic_and.6.aspx}},
volume = {{12}},
year = {{1988}},
}