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Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites

Ferraro, Giarita ; Pica, Andrea ; Petruk, Ganna LU orcid ; Pane, Francesca ; Amoresano, Angela ; Cilibrizzi, Agostino ; Vilar, Ramon ; Monti, Daria Maria and Merlino, Antonello (2018) In Nanomedicine 13(23). p.2995-3007
Abstract

Aim: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2′ of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). Materials & methods: Spectroscopic and crystallographic data of the Pt(II)-AFt nanocomposite have been collected and in vitro anticancer activity has been explored using cancer cells. Results: Pt(II)-containing fragments bind His49, His114 and His132. Pt(II)-AFt nanocomposite is less cytotoxic than 1, but it is more toxic than cisplatin at high concentrations. The Pt(II)-AFt nanocomposite triggers necrosis in cancer cells, as free 1 does. Conclusion: Pt(II)-AFt nanocomposites... (More)

Aim: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2′ of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). Materials & methods: Spectroscopic and crystallographic data of the Pt(II)-AFt nanocomposite have been collected and in vitro anticancer activity has been explored using cancer cells. Results: Pt(II)-containing fragments bind His49, His114 and His132. Pt(II)-AFt nanocomposite is less cytotoxic than 1, but it is more toxic than cisplatin at high concentrations. The Pt(II)-AFt nanocomposite triggers necrosis in cancer cells, as free 1 does. Conclusion: Pt(II)-AFt nanocomposites are promising vehicles to deliver Pt-based drugs to cancer cells.

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author
; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
platinum-based drug, protein metalation, protein nanocage, protein-metallodrug interactions, Pt(II)-terpyridine compounds
in
Nanomedicine
volume
13
issue
23
pages
2995 - 3007
publisher
Taylor & Francis
external identifiers
  • pmid:30501559
  • scopus:85058086378
ISSN
1743-5889
DOI
10.2217/nnm-2018-0259
language
English
LU publication?
no
additional info
Publisher Copyright: © 2018 2018 Future Medicine Ltd.
id
bb3e5234-fccd-4b98-b604-57d9fc47702e
date added to LUP
2025-01-21 15:45:56
date last changed
2025-04-29 22:50:55
@article{bb3e5234-fccd-4b98-b604-57d9fc47702e,
  abstract     = {{<p>Aim: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2′ of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). Materials &amp; methods: Spectroscopic and crystallographic data of the Pt(II)-AFt nanocomposite have been collected and in vitro anticancer activity has been explored using cancer cells. Results: Pt(II)-containing fragments bind His49, His114 and His132. Pt(II)-AFt nanocomposite is less cytotoxic than 1, but it is more toxic than cisplatin at high concentrations. The Pt(II)-AFt nanocomposite triggers necrosis in cancer cells, as free 1 does. Conclusion: Pt(II)-AFt nanocomposites are promising vehicles to deliver Pt-based drugs to cancer cells.</p>}},
  author       = {{Ferraro, Giarita and Pica, Andrea and Petruk, Ganna and Pane, Francesca and Amoresano, Angela and Cilibrizzi, Agostino and Vilar, Ramon and Monti, Daria Maria and Merlino, Antonello}},
  issn         = {{1743-5889}},
  keywords     = {{platinum-based drug; protein metalation; protein nanocage; protein-metallodrug interactions; Pt(II)-terpyridine compounds}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{23}},
  pages        = {{2995--3007}},
  publisher    = {{Taylor & Francis}},
  series       = {{Nanomedicine}},
  title        = {{Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites}},
  url          = {{http://dx.doi.org/10.2217/nnm-2018-0259}},
  doi          = {{10.2217/nnm-2018-0259}},
  volume       = {{13}},
  year         = {{2018}},
}