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Micro ct analysis of sellar floor in pituitary adenomas, especially in Cushing's disease

Berker, M. ; Hazer, Derya Burcu LU orcid ; Çehreli, M. ; Salmon, P. ; Akça, K. and Tekdemir, I. (2010) In Acta Endocrinologica 6(4). p.481-492
Abstract

Context. The aim of this study was to explore the prognostic significance correlation between the endocrinopathy and the size of the pituitary adenoma with the sellar floor bone mineral density values using microfocus computerized tomography (μCT) analysis. Subjects and Methods. 16 consecutive patients with pituitary adenomas had full endocrinological and radiological work up prior to endoscopic transnasal transsphenoidal surgery. Multiple bony samples were collected from the sellar floor during surgery, and labeled and analyzed in a double blind fashion. Each bone sample was analyzed for bone mineral density (BMD) and Hounsfield units (HU) with microfocus CT. Results. There was no correlation between adenoma size and BMD values of... (More)

Context. The aim of this study was to explore the prognostic significance correlation between the endocrinopathy and the size of the pituitary adenoma with the sellar floor bone mineral density values using microfocus computerized tomography (μCT) analysis. Subjects and Methods. 16 consecutive patients with pituitary adenomas had full endocrinological and radiological work up prior to endoscopic transnasal transsphenoidal surgery. Multiple bony samples were collected from the sellar floor during surgery, and labeled and analyzed in a double blind fashion. Each bone sample was analyzed for bone mineral density (BMD) and Hounsfield units (HU) with microfocus CT. Results. There was no correlation between adenoma size and BMD values of sella floor but grade IV macroadenomas were found to have lower BMD levels. Statistical analysis showed that the level of correlation between grouped BMD (<1.0 and >1.0) data with ACTH (<46 and >46), IGF (<303 and >303), and PRL (<29.93 and >29.93) levels were insignificant (P=.569, P=.315, and P=1.00, respectively) Conclusion. We have found no clinical relationship between sellar floor BMD values and endocrinopathy and the size of the adenoma. However, it was found out that preoperative conventional CT evaluation seemed insufficient in predicting the sellar floor bone integrity and may mislead the surgeon.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Cushing disease, Erosion, Microfocus computerized tomography, Pituitary adenoma, Sella turcica
in
Acta Endocrinologica
volume
6
issue
4
pages
481 - 492
publisher
Acta Endocrinologica Foundation
external identifiers
  • scopus:79960436669
ISSN
1841-0987
DOI
10.4183/aeb.2010.481
language
English
LU publication?
no
id
bc71c712-df53-46aa-9a05-da95e6fbf437
date added to LUP
2025-05-11 22:41:31
date last changed
2025-05-13 13:22:28
@article{bc71c712-df53-46aa-9a05-da95e6fbf437,
  abstract     = {{<p>Context. The aim of this study was to explore the prognostic significance correlation between the endocrinopathy and the size of the pituitary adenoma with the sellar floor bone mineral density values using microfocus computerized tomography (μCT) analysis. Subjects and Methods. 16 consecutive patients with pituitary adenomas had full endocrinological and radiological work up prior to endoscopic transnasal transsphenoidal surgery. Multiple bony samples were collected from the sellar floor during surgery, and labeled and analyzed in a double blind fashion. Each bone sample was analyzed for bone mineral density (BMD) and Hounsfield units (HU) with microfocus CT. Results. There was no correlation between adenoma size and BMD values of sella floor but grade IV macroadenomas were found to have lower BMD levels. Statistical analysis showed that the level of correlation between grouped BMD (&lt;1.0 and &gt;1.0) data with ACTH (&lt;46 and &gt;46), IGF (&lt;303 and &gt;303), and PRL (&lt;29.93 and &gt;29.93) levels were insignificant (P=.569, P=.315, and P=1.00, respectively) Conclusion. We have found no clinical relationship between sellar floor BMD values and endocrinopathy and the size of the adenoma. However, it was found out that preoperative conventional CT evaluation seemed insufficient in predicting the sellar floor bone integrity and may mislead the surgeon.</p>}},
  author       = {{Berker, M. and Hazer, Derya Burcu and Çehreli, M. and Salmon, P. and Akça, K. and Tekdemir, I.}},
  issn         = {{1841-0987}},
  keywords     = {{Cushing disease; Erosion; Microfocus computerized tomography; Pituitary adenoma; Sella turcica}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{481--492}},
  publisher    = {{Acta Endocrinologica Foundation}},
  series       = {{Acta Endocrinologica}},
  title        = {{Micro ct analysis of sellar floor in pituitary adenomas, especially in Cushing's disease}},
  url          = {{http://dx.doi.org/10.4183/aeb.2010.481}},
  doi          = {{10.4183/aeb.2010.481}},
  volume       = {{6}},
  year         = {{2010}},
}