De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation
Bilginer, Burcak ; Türk, Cezmi Cagrı ; Narin, Fırat ; Hazer, Burcu LU
; Hanalioglu, Sahin
; Oguz, Kader Karlı
; Soylemezoglu, Figen
and Akalan, Nejat
(2015)
In Child's Nervous System
31(6).
p.893-899
- Abstract
Purpose: Tumors of central nervous system (CNS) are accounted as the second most common tumors in childhood (21 % of all cancers) following hematologic malignancies. The patients can suffer more than one cancer in their lifetime, and radiotherapy is claimed for de novo formation of a new tumor in years after treatment of an initial tumor. Methods: We have retrospectively analyzed our database for defining radiotherapy-related de novo brain tumors operated in between January, 2000 and August, 2012. New tumors in the field of radiotherapy were included into the study. Results: The retrospective analysis revealed six patients (two girls and four boys) eligible for further evaluation. The children were irradiated at an age in the range of 5... (More)
Purpose: Tumors of central nervous system (CNS) are accounted as the second most common tumors in childhood (21 % of all cancers) following hematologic malignancies. The patients can suffer more than one cancer in their lifetime, and radiotherapy is claimed for de novo formation of a new tumor in years after treatment of an initial tumor. Methods: We have retrospectively analyzed our database for defining radiotherapy-related de novo brain tumors operated in between January, 2000 and August, 2012. New tumors in the field of radiotherapy were included into the study. Results: The retrospective analysis revealed six patients (two girls and four boys) eligible for further evaluation. The children were irradiated at an age in the range of 5 and 12 years (mean, 7.8). The primary diagnoses were hematological malignancies in two (acute lymphocytic leukemia and non-Hodgkin lymphoma (NHL)) and solid tumors in other four (two pilocytic astrocytoma, one craniopharyngioma, and one grade 3 astrocytoma). All patients received cranial radiotherapy. The mean latency period for the “second tumor” was 9.5 years. The pathological diagnoses for de novo new tumors were as follows: glial tumor (two cases), medulloblastoma (two cases), mesenchymal tumor (one case), and meningeal sarcoma (one case). All de novo tumors were high graded. Mean survival was 14.6 months. Conclusions: de novo brain tumors after irradiation has poor prognosis in neurosurgical practice. Vigilance and awareness for possibility of de novo new tumor are warranted for both families and physicians at follow-ups even years after the treatment of initial tumors.
(Less)
- author
- Bilginer, Burcak
; Türk, Cezmi Cagrı
; Narin, Fırat
; Hazer, Burcu
LU
; Hanalioglu, Sahin
; Oguz, Kader Karlı
; Soylemezoglu, Figen
and Akalan, Nejat
- publishing date
- 2015-06-29
- type
- Contribution to journal
- publication status
- published
- keywords
- Central nervous system, Childhood, De novo, Radiation, Second, Tumor
- in
- Child's Nervous System
- volume
- 31
- issue
- 6
- pages
- 893 - 899
- publisher
- Springer
- external identifiers
-
- scopus:84929955592
- pmid:25831997
- ISSN
- 0256-7040
- DOI
- 10.1007/s00381-015-2689-3
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2015, Springer-Verlag Berlin Heidelberg.
- id
- bd08d7a2-7d51-41ff-903e-4f5eaa21a238
- date added to LUP
- 2025-05-11 22:36:58
- date last changed
- 2025-05-13 03:16:29
@article{bd08d7a2-7d51-41ff-903e-4f5eaa21a238,
abstract = {{<p>Purpose: Tumors of central nervous system (CNS) are accounted as the second most common tumors in childhood (21 % of all cancers) following hematologic malignancies. The patients can suffer more than one cancer in their lifetime, and radiotherapy is claimed for de novo formation of a new tumor in years after treatment of an initial tumor. Methods: We have retrospectively analyzed our database for defining radiotherapy-related de novo brain tumors operated in between January, 2000 and August, 2012. New tumors in the field of radiotherapy were included into the study. Results: The retrospective analysis revealed six patients (two girls and four boys) eligible for further evaluation. The children were irradiated at an age in the range of 5 and 12 years (mean, 7.8). The primary diagnoses were hematological malignancies in two (acute lymphocytic leukemia and non-Hodgkin lymphoma (NHL)) and solid tumors in other four (two pilocytic astrocytoma, one craniopharyngioma, and one grade 3 astrocytoma). All patients received cranial radiotherapy. The mean latency period for the “second tumor” was 9.5 years. The pathological diagnoses for de novo new tumors were as follows: glial tumor (two cases), medulloblastoma (two cases), mesenchymal tumor (one case), and meningeal sarcoma (one case). All de novo tumors were high graded. Mean survival was 14.6 months. Conclusions: de novo brain tumors after irradiation has poor prognosis in neurosurgical practice. Vigilance and awareness for possibility of de novo new tumor are warranted for both families and physicians at follow-ups even years after the treatment of initial tumors.</p>}},
author = {{Bilginer, Burcak and Türk, Cezmi Cagrı and Narin, Fırat and Hazer, Burcu and Hanalioglu, Sahin and Oguz, Kader Karlı and Soylemezoglu, Figen and Akalan, Nejat}},
issn = {{0256-7040}},
keywords = {{Central nervous system; Childhood; De novo; Radiation; Second; Tumor}},
language = {{eng}},
month = {{06}},
number = {{6}},
pages = {{893--899}},
publisher = {{Springer}},
series = {{Child's Nervous System}},
title = {{De novo formation of brain tumors in pediatric population following therapeutic cranial irradiation}},
url = {{http://dx.doi.org/10.1007/s00381-015-2689-3}},
doi = {{10.1007/s00381-015-2689-3}},
volume = {{31}},
year = {{2015}},
}