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Defining early vascular aging in youth : an expert consensus document from the youth vascular consortium

Kruger, Ruan ; Hersant, Jeanne ; Kodithuwakku, Vimarsha ; Strauss-Kruger, Michél ; Sinha, Manish D. ; Johansson, Madeleine LU orcid ; Litwin, Mieczysław ; Hanssen, Henner ; Königstein, Karsten and Hidvégi, Erzsébet V. , et al. (2025) In Journal of Hypertension 43.
Abstract

The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/ or functional characteristics of the macrovascular and/or microvascular system may deviate from that expected for the chronological age of the individual. Assessing vascular aging from a young age may help detect and prevent the early onset of cardiovascular disease. This consensus document from the... (More)

The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/ or functional characteristics of the macrovascular and/or microvascular system may deviate from that expected for the chronological age of the individual. Assessing vascular aging from a young age may help detect and prevent the early onset of cardiovascular disease. This consensus document from the Youth Vascular Consortium outlines the principles of EVA in youth (birth to 24years), examines factors influencing vascular growth, and identifies current knowledge gaps. It also provides an expert consensus on defining EVA in youth. Supplementary Tables 1–3, http://links.lww.com/HJH/C733, http://links.lww.com/HJH/C734,http://links.lww.com/HJH/C735 supply key references for risk factors associated with EVA at different points in development; 1. Neonates to childhood; 2. Adolescence; 3. Young adults. Supplementary Table 4, http://links.lww.com/HJH/C736 displays reference ranges of EVA in adults.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adolescence, arterial aging, arterial stiffness, arteriosclerosis, atherosclerosis, biological maturation, childhood, early vascular aging, pulse wave velocity
in
Journal of Hypertension
volume
43
article number
10.1097/HJH.0000000000004056
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:105008118330
  • pmid:40825154
ISSN
0263-6352
DOI
10.1097/HJH.0000000000004056
language
English
LU publication?
yes
additional info
Publisher Copyright: Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.
id
bdecf19e-1c06-4550-b224-a032fdaea2f2
date added to LUP
2026-01-29 14:54:51
date last changed
2026-01-30 07:23:03
@article{bdecf19e-1c06-4550-b224-a032fdaea2f2,
  abstract     = {{<p>The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/ or functional characteristics of the macrovascular and/or microvascular system may deviate from that expected for the chronological age of the individual. Assessing vascular aging from a young age may help detect and prevent the early onset of cardiovascular disease. This consensus document from the Youth Vascular Consortium outlines the principles of EVA in youth (birth to 24years), examines factors influencing vascular growth, and identifies current knowledge gaps. It also provides an expert consensus on defining EVA in youth. Supplementary Tables 1–3, http://links.lww.com/HJH/C733, http://links.lww.com/HJH/C734,http://links.lww.com/HJH/C735 supply key references for risk factors associated with EVA at different points in development; 1. Neonates to childhood; 2. Adolescence; 3. Young adults. Supplementary Table 4, http://links.lww.com/HJH/C736 displays reference ranges of EVA in adults.</p>}},
  author       = {{Kruger, Ruan and Hersant, Jeanne and Kodithuwakku, Vimarsha and Strauss-Kruger, Michél and Sinha, Manish D. and Johansson, Madeleine and Litwin, Mieczysław and Hanssen, Henner and Königstein, Karsten and Hidvégi, Erzsébet V. and Stoner, Lee and Stone, Keeron and Pugh, Christopher J.A. and Mels, Catharina M.C. and Breet, Yolandi and Smith, Wayne and Bia, Daniel and Zócalo, Yanina and Diaz, Alejandro and Khadilkar, Anuradha and Dharnidharka, Vikas R. and Pucci, Giacomo and Urbina, Elaine M. and Bruno, Rosa Maria and Nilsson, Peter M. and Climie, Rachel E.}},
  issn         = {{0263-6352}},
  keywords     = {{adolescence; arterial aging; arterial stiffness; arteriosclerosis; atherosclerosis; biological maturation; childhood; early vascular aging; pulse wave velocity}},
  language     = {{eng}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{Defining early vascular aging in youth : an expert consensus document from the youth vascular consortium}},
  url          = {{http://dx.doi.org/10.1097/HJH.0000000000004056}},
  doi          = {{10.1097/HJH.0000000000004056}},
  volume       = {{43}},
  year         = {{2025}},
}