Significance of understanding the genomics of host-pathogen interaction in limiting antibiotic resistance development : Lessons from COVID-19 pandemic
(2024) In Briefings in Functional Genomics 23(1). p.69-74- Abstract
The entire world is facing the stiff challenge of COVID-19 pandemic. To overcome the spread of this highly infectious disease, several short-sighted strategies were adopted such as the use of broad-spectrum antibiotics and antifungals. However, the misuse and/or overuse of antibiotics have accentuated the emergence of the next pandemic: Antimicrobial resistance (AMR). It is believed that pathogens while transferring between humans and the environment carry virulence and antibiotic-resistant factors from varied species. It is presumed that all such genetic factors are quantifiable and predictable, a better understanding of which could be a limiting step for the progression of AMR. Herein, we have reviewed how genomics-based understanding... (More)
The entire world is facing the stiff challenge of COVID-19 pandemic. To overcome the spread of this highly infectious disease, several short-sighted strategies were adopted such as the use of broad-spectrum antibiotics and antifungals. However, the misuse and/or overuse of antibiotics have accentuated the emergence of the next pandemic: Antimicrobial resistance (AMR). It is believed that pathogens while transferring between humans and the environment carry virulence and antibiotic-resistant factors from varied species. It is presumed that all such genetic factors are quantifiable and predictable, a better understanding of which could be a limiting step for the progression of AMR. Herein, we have reviewed how genomics-based understanding of host-pathogen interactions during COVID-19 could reduce the non-judicial use of antibiotics and prevent the eruption of an AMR-based pandemic in future.
(Less)
- author
- Yadav, Vikas LU and Ravichandran, Srividhya
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antibiotics, COVID-19, genomics, host-pathogen interactions, pandemics
- in
- Briefings in Functional Genomics
- volume
- 23
- issue
- 1
- pages
- 6 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:36722037
- scopus:85182881204
- ISSN
- 2041-2649
- DOI
- 10.1093/bfgp/elad001
- language
- English
- LU publication?
- yes
- id
- bf2e483e-6929-4786-86c0-69d2012fe792
- date added to LUP
- 2024-02-19 14:06:48
- date last changed
- 2024-11-16 14:29:53
@article{bf2e483e-6929-4786-86c0-69d2012fe792,
abstract = {{<p>The entire world is facing the stiff challenge of COVID-19 pandemic. To overcome the spread of this highly infectious disease, several short-sighted strategies were adopted such as the use of broad-spectrum antibiotics and antifungals. However, the misuse and/or overuse of antibiotics have accentuated the emergence of the next pandemic: Antimicrobial resistance (AMR). It is believed that pathogens while transferring between humans and the environment carry virulence and antibiotic-resistant factors from varied species. It is presumed that all such genetic factors are quantifiable and predictable, a better understanding of which could be a limiting step for the progression of AMR. Herein, we have reviewed how genomics-based understanding of host-pathogen interactions during COVID-19 could reduce the non-judicial use of antibiotics and prevent the eruption of an AMR-based pandemic in future.</p>}},
author = {{Yadav, Vikas and Ravichandran, Srividhya}},
issn = {{2041-2649}},
keywords = {{antibiotics; COVID-19; genomics; host-pathogen interactions; pandemics}},
language = {{eng}},
number = {{1}},
pages = {{69--74}},
publisher = {{Oxford University Press}},
series = {{Briefings in Functional Genomics}},
title = {{Significance of understanding the genomics of host-pathogen interaction in limiting antibiotic resistance development : Lessons from COVID-19 pandemic}},
url = {{http://dx.doi.org/10.1093/bfgp/elad001}},
doi = {{10.1093/bfgp/elad001}},
volume = {{23}},
year = {{2024}},
}