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Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Cross-sectional assessment of frontal-cortex glutathione, GABA, and glutamate in individuals with relapsing-remitting and progressive multiple sclerosis

Swanberg, Kelley LU orcid ; Prinsen, Hetty ; Coman, Daniel ; Rothman, Douglas L. ; DeGraaf, Robin A. and Juchem, Christoph (2017) 2017.
Abstract
Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS patients and controls to explore the effects of disease state on concentrations of brain metabolites like glutathione, GABA, glutamate, and N-acetyl aspartate (NAA). Our results suggest an age- and disease-related decrease in glutamate, as well as a disease-related decrease in NAA, in patients with P-MS relative to RR-MS and controls without MS. No... (More)
Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS patients and controls to explore the effects of disease state on concentrations of brain metabolites like glutathione, GABA, glutamate, and N-acetyl aspartate (NAA). Our results suggest an age- and disease-related decrease in glutamate, as well as a disease-related decrease in NAA, in patients with P-MS relative to RR-MS and controls without MS. No disease-related changes in GSH or GABA were found. Our data underscore the importance of continued investigation into the potential physiological distinctions among various MS subtypes. (Less)
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type
Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Proc Int Soc Magn Reson Med
volume
2017
language
English
LU publication?
no
id
c272c742-5b30-42b3-92e9-0c374d7be188
alternative location
https://archive.ismrm.org/2017/2970.html
date added to LUP
2023-09-18 15:57:18
date last changed
2023-09-19 12:32:04
@inproceedings{c272c742-5b30-42b3-92e9-0c374d7be188,
  abstract     = {{Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS patients and controls to explore the effects of disease state on concentrations of brain metabolites like glutathione, GABA, glutamate, and N-acetyl aspartate (NAA). Our results suggest an age- and disease-related decrease in glutamate, as well as a disease-related decrease in NAA, in patients with P-MS relative to RR-MS and controls without MS. No disease-related changes in GSH or GABA were found. Our data underscore the importance of continued investigation into the potential physiological distinctions among various MS subtypes.}},
  author       = {{Swanberg, Kelley and Prinsen, Hetty and Coman, Daniel and Rothman, Douglas L. and DeGraaf, Robin A. and Juchem, Christoph}},
  booktitle    = {{Proc Int Soc Magn Reson Med}},
  language     = {{eng}},
  title        = {{Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Cross-sectional assessment of frontal-cortex glutathione, GABA, and glutamate in individuals with relapsing-remitting and progressive multiple sclerosis}},
  url          = {{https://archive.ismrm.org/2017/2970.html}},
  volume       = {{2017}},
  year         = {{2017}},
}