Prognostic nomogram for acute-on-chronic hepatitis B liver failure
Lin, Su ; Chen, Juan ; Wang, Mingfang ; Han, Lifen ; Zhang, Haoyang LU
; Dong, Jing
; Zeng, Dawu
; Jiang, Jiaji
and Zhu, Yueyong
(2017)
In Oncotarget
8(65).
p.109772-109782
- Abstract
BACKGROUND & AIMS: To establish an effective prognostic nomogram for acute-on-chronic hepatitis B liver failure (ACHBLF).
MATERIALS AND METHODS: The nomogram was based on clinical data of 203 ACHBLF patients who admitted to the First Affiliated Hospital of Fujian Medical University from 2009 to 2014. The area under the receiver-operating characteristic curve (AUC) and calibration curve were carried out to verify the predictive accuracy ability of the nomogram. The result was validated in internal and external validation cohorts. Kaplan-Meier survival curve was used in survival analysis.
RESULTS: We developed a new prognostic nomogram to predict 3-month mortality based on risk factors selected by multivariate analysis.... (More)
BACKGROUND & AIMS: To establish an effective prognostic nomogram for acute-on-chronic hepatitis B liver failure (ACHBLF).
MATERIALS AND METHODS: The nomogram was based on clinical data of 203 ACHBLF patients who admitted to the First Affiliated Hospital of Fujian Medical University from 2009 to 2014. The area under the receiver-operating characteristic curve (AUC) and calibration curve were carried out to verify the predictive accuracy ability of the nomogram. The result was validated in internal and external validation cohorts. Kaplan-Meier survival curve was used in survival analysis.
RESULTS: We developed a new prognostic nomogram to predict 3-month mortality based on risk factors selected by multivariate analysis. This nomogram consisted three independent factors: age, liver to abdominal area ratio (LAAR) and model for end-stage liver disease (MELD) score. The AUC of this nomogram for survival prediction was 0.877 (95% CI 0.831-0.923), which was higher than that of MELD score, MELD-Na and Child-Turcotte-Pugh (CTP). Good agreement of calibration plot for the probability of survival at 3-month was shown between the prediction by nomogram and actual observation. These results were supported by internal and external validation studies.
CONCLUSIONS: The ACHBLF nomogram could predict the short-term survival for ACHBLF patients.
(Less)
- author
- Lin, Su
; Chen, Juan
; Wang, Mingfang
; Han, Lifen
; Zhang, Haoyang
LU
; Dong, Jing
; Zeng, Dawu
; Jiang, Jiaji
and Zhu, Yueyong
- publishing date
- 2017-12-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Oncotarget
- volume
- 8
- issue
- 65
- pages
- 109772 - 109782
- publisher
- Impact Journals
- external identifiers
-
- pmid:29312647
- scopus:85037681191
- ISSN
- 1949-2553
- DOI
- 10.18632/oncotarget.21012
- language
- English
- LU publication?
- no
- id
- c29932ef-bb35-45bd-8bda-ff726adc7271
- date added to LUP
- 2024-02-05 16:15:43
- date last changed
- 2025-04-04 14:44:49
@article{c29932ef-bb35-45bd-8bda-ff726adc7271,
abstract = {{<p>BACKGROUND & AIMS: To establish an effective prognostic nomogram for acute-on-chronic hepatitis B liver failure (ACHBLF).</p><p>MATERIALS AND METHODS: The nomogram was based on clinical data of 203 ACHBLF patients who admitted to the First Affiliated Hospital of Fujian Medical University from 2009 to 2014. The area under the receiver-operating characteristic curve (AUC) and calibration curve were carried out to verify the predictive accuracy ability of the nomogram. The result was validated in internal and external validation cohorts. Kaplan-Meier survival curve was used in survival analysis.</p><p>RESULTS: We developed a new prognostic nomogram to predict 3-month mortality based on risk factors selected by multivariate analysis. This nomogram consisted three independent factors: age, liver to abdominal area ratio (LAAR) and model for end-stage liver disease (MELD) score. The AUC of this nomogram for survival prediction was 0.877 (95% CI 0.831-0.923), which was higher than that of MELD score, MELD-Na and Child-Turcotte-Pugh (CTP). Good agreement of calibration plot for the probability of survival at 3-month was shown between the prediction by nomogram and actual observation. These results were supported by internal and external validation studies.</p><p>CONCLUSIONS: The ACHBLF nomogram could predict the short-term survival for ACHBLF patients.</p>}},
author = {{Lin, Su and Chen, Juan and Wang, Mingfang and Han, Lifen and Zhang, Haoyang and Dong, Jing and Zeng, Dawu and Jiang, Jiaji and Zhu, Yueyong}},
issn = {{1949-2553}},
language = {{eng}},
month = {{12}},
number = {{65}},
pages = {{109772--109782}},
publisher = {{Impact Journals}},
series = {{Oncotarget}},
title = {{Prognostic nomogram for acute-on-chronic hepatitis B liver failure}},
url = {{http://dx.doi.org/10.18632/oncotarget.21012}},
doi = {{10.18632/oncotarget.21012}},
volume = {{8}},
year = {{2017}},
}