Effect of Cimetidine on Survival after gastric cancer
(1988) In The Lancet 332(8618). p.990-992- Abstract
The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.
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- author
- publishing date
- 1988-10-29
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The Lancet
- volume
- 332
- issue
- 8618
- pages
- 3 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:2902494
- scopus:0023816023
- ISSN
- 0140-6736
- DOI
- 10.1016/S0140-6736(88)90743-X
- language
- English
- LU publication?
- no
- id
- c32e6e05-156d-4271-a5e2-144ac26da392
- date added to LUP
- 2018-11-01 14:08:04
- date last changed
- 2024-04-15 16:52:46
@article{c32e6e05-156d-4271-a5e2-144ac26da392, abstract = {{<p>The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.</p>}}, author = {{Tonnesen, Hanne and Bülow, Steffen and Fischerman, Kaj and Hjortrup, Allan and Møller Pedersen, Vilhelm and Bo Svendsen, Lars and Knigge, Ulrich and Damm, Peter and Hesselfeldt, Peter and Krogh Pedersen, Ib and Julius Siemssen, Ole and Martin Christiansen, Poul}}, issn = {{0140-6736}}, language = {{eng}}, month = {{10}}, number = {{8618}}, pages = {{990--992}}, publisher = {{Elsevier}}, series = {{The Lancet}}, title = {{Effect of Cimetidine on Survival after gastric cancer}}, url = {{http://dx.doi.org/10.1016/S0140-6736(88)90743-X}}, doi = {{10.1016/S0140-6736(88)90743-X}}, volume = {{332}}, year = {{1988}}, }