Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Delivery of a sebum modulator by an engineered skin microbe in mice

Knödlseder, Nastassia ; Fábrega, María José ; Santos-Moreno, Javier ; Manils, Joan ; Toloza, Lorena ; Marín Vilar, Maria ; Fernández, Cristina ; Broadbent, Katrina ; Maruotti, Julien and Lemenager, Hélène , et al. (2024) In Nature Biotechnology 42(11). p.1661-1666
Abstract

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.

Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Biotechnology
volume
42
issue
11
pages
1661 - 1666
publisher
Nature Publishing Group
external identifiers
  • scopus:85181877380
  • pmid:38195987
ISSN
1087-0156
DOI
10.1038/s41587-023-02072-4
language
English
LU publication?
yes
id
c40c3561-1507-4f38-ad38-c8b7a0594474
date added to LUP
2024-02-09 14:58:59
date last changed
2025-01-29 20:43:34
@article{c40c3561-1507-4f38-ad38-c8b7a0594474,
  abstract     = {{<p>Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.</p>}},
  author       = {{Knödlseder, Nastassia and Fábrega, María José and Santos-Moreno, Javier and Manils, Joan and Toloza, Lorena and Marín Vilar, Maria and Fernández, Cristina and Broadbent, Katrina and Maruotti, Julien and Lemenager, Hélène and Carolis, Carlo and Zouboulis, Christos C. and Soler, Concepció and Lood, Rolf and Brüggemann, Holger and Güell, Marc}},
  issn         = {{1087-0156}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1661--1666}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Biotechnology}},
  title        = {{Delivery of a sebum modulator by an engineered skin microbe in mice}},
  url          = {{http://dx.doi.org/10.1038/s41587-023-02072-4}},
  doi          = {{10.1038/s41587-023-02072-4}},
  volume       = {{42}},
  year         = {{2024}},
}