Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality
(2021) In Angiology 72(6). p.550-555- Abstract
We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and copeptin. Participants were followed up for incident PAD and mortality until December 31, 2016. Median follow-up was 11.2 years (interquartile range 9.4-12.2). Cumulative incidence of PAD was 4.3% (221/5160), 4.5% in men (164/3618) and 3.7% in women (57/1542; P =.174). In an adjusted Cox proportional hazards regression model, higher... (More)
We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and copeptin. Participants were followed up for incident PAD and mortality until December 31, 2016. Median follow-up was 11.2 years (interquartile range 9.4-12.2). Cumulative incidence of PAD was 4.3% (221/5160), 4.5% in men (164/3618) and 3.7% in women (57/1542; P =.174). In an adjusted Cox proportional hazards regression model, higher CT-proET-1 (hazard ratio [HR] 1.8; 95% confidence interval [CI] 1.4-2.3), NT-proSST (HR 1.5; 95% CI 1.2-2.0), and MR-proANP (HR 1.7; 95% CI 1.3-2.3) were independently associated with incident PAD, and higher CT-proET-1 (HR 1.3; 95% CI 1.2-1.5), NT-proSST (HR 1.2; 95% CI 1.1-1.3), MR-proANP (HR 1.4; 95% CI 1.3-1.6), PCT (HR 1.1; 95% CI 1.0-1.2), and copeptin (HR 1.2; 95% CI 1.1-1.4) were independently associated with mortality. Increased levels of CT-proET-1, NT-proSST, and MR-proANP were independently associated with incident PAD, whereas all the vasoactive biomarkers were independently associated with mortality during follow-up.
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- author
- Dakhel, Ardwan LU ; Engström, Gunnar LU ; Melander, Olle LU ; Acosta, Stefan LU ; Fatemi, Shahab LU ; Gottsäter, Anders LU and Zarrouk, Moncef LU
- organization
-
- Vascular Diseases - Clinical Research (research group)
- Cardiovascular Research - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Hypertension (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2021-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atherosclerosis, biomarkers, peripheral arterial disease
- in
- Angiology
- volume
- 72
- issue
- 6
- pages
- 6 pages
- publisher
- SAGE Publications
- external identifiers
-
- pmid:33504164
- scopus:85100458433
- ISSN
- 0003-3197
- DOI
- 10.1177/0003319720987739
- language
- English
- LU publication?
- yes
- id
- c53b1446-d71f-462c-b1ee-3e1ecb49304c
- date added to LUP
- 2021-02-18 10:10:53
- date last changed
- 2024-10-03 19:01:37
@article{c53b1446-d71f-462c-b1ee-3e1ecb49304c, abstract = {{<p>We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and copeptin. Participants were followed up for incident PAD and mortality until December 31, 2016. Median follow-up was 11.2 years (interquartile range 9.4-12.2). Cumulative incidence of PAD was 4.3% (221/5160), 4.5% in men (164/3618) and 3.7% in women (57/1542; P =.174). In an adjusted Cox proportional hazards regression model, higher CT-proET-1 (hazard ratio [HR] 1.8; 95% confidence interval [CI] 1.4-2.3), NT-proSST (HR 1.5; 95% CI 1.2-2.0), and MR-proANP (HR 1.7; 95% CI 1.3-2.3) were independently associated with incident PAD, and higher CT-proET-1 (HR 1.3; 95% CI 1.2-1.5), NT-proSST (HR 1.2; 95% CI 1.1-1.3), MR-proANP (HR 1.4; 95% CI 1.3-1.6), PCT (HR 1.1; 95% CI 1.0-1.2), and copeptin (HR 1.2; 95% CI 1.1-1.4) were independently associated with mortality. Increased levels of CT-proET-1, NT-proSST, and MR-proANP were independently associated with incident PAD, whereas all the vasoactive biomarkers were independently associated with mortality during follow-up.</p>}}, author = {{Dakhel, Ardwan and Engström, Gunnar and Melander, Olle and Acosta, Stefan and Fatemi, Shahab and Gottsäter, Anders and Zarrouk, Moncef}}, issn = {{0003-3197}}, keywords = {{atherosclerosis; biomarkers; peripheral arterial disease}}, language = {{eng}}, month = {{07}}, number = {{6}}, pages = {{550--555}}, publisher = {{SAGE Publications}}, series = {{Angiology}}, title = {{Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality}}, url = {{http://dx.doi.org/10.1177/0003319720987739}}, doi = {{10.1177/0003319720987739}}, volume = {{72}}, year = {{2021}}, }