Breathlessness, Anxiety, Depression, and Function–The BAD-F Study : A Cross-Sectional and Population Prevalence Study in Adults
Currow, David C. ; Chang, Sungwon ; Reddel, Helen K. ; Kochovska, Slavica ; Ferreira, Diana ; Kinchin, Irina ; Johnson, Miriam and Ekström, Magnus LU
(2020)
In Journal of Pain and Symptom Management
59(2).
p.2-205
- Abstract
Context: Breathlessness is associated with depression, but its relationship to anxiety or impaired function is less clear. Objectives: This study evaluated associations between chronic breathlessness and anxiety, depression, and functional status in the general population. Methods: This cross-sectional study of consenting adults (18 years and older) used an online survey. Quota sampling (n = 3000) was used reflecting the 2016 national census for sex, age, and place of residence. Other data included Four-Item Patient Health Questionnaire for depression and anxiety, the modified Medical Research Council (mMRC) Breathlessness Scale, and the Australia-modified Karnofsky Performance Scale. Multinomial logistic regression assessed predictors.... (More)
Context: Breathlessness is associated with depression, but its relationship to anxiety or impaired function is less clear. Objectives: This study evaluated associations between chronic breathlessness and anxiety, depression, and functional status in the general population. Methods: This cross-sectional study of consenting adults (18 years and older) used an online survey. Quota sampling (n = 3000) was used reflecting the 2016 national census for sex, age, and place of residence. Other data included Four-Item Patient Health Questionnaire for depression and anxiety, the modified Medical Research Council (mMRC) Breathlessness Scale, and the Australia-modified Karnofsky Performance Scale. Multinomial logistic regression assessed predictors. Results: About 2977 respondents had all relevant scores (female 51.2%; median age 45.0 [range 18–92]). Prevalence of breathlessness (mMRC ≥2) was 2.4%, anxiety 6.0%, depression 2.7%, coexisting anxiety/depression 6.1%, and poorer functional status (Australia-modified Karnofsky Performance Scale ≤60) 1.6%. In multinomial regression, depression, anxiety, and coexisting anxiety/depression were predicted by younger age, longer duration of breathlessness, and poorer functional status. The highest proportions of people with breathlessness were found in the coexisting anxiety/depression group (10.6%) and depression only group (8.8%). Poorest function was in the coexisting anxiety/depression group with 11.6%. The relationship between poorer functional status and coexisting anxiety/depression was significant (odds ratio 0.90; 95% CI 0.89, 0.92). Adjusted odds ratio for breathlessness and depression only was 3.0 (95% CI 1.2, 7.8). Conclusion: Clinically important breathlessness (mMRC ≥2) was associated with depression, anxiety, and coexisting anxiety/depression. Poorer function that is associated with psychological morbidity in the general population requires further research.
(Less)
- author
- Currow, David C.
; Chang, Sungwon
; Reddel, Helen K.
; Kochovska, Slavica
; Ferreira, Diana
; Kinchin, Irina
; Johnson, Miriam
and Ekström, Magnus
LU
- organization
- publishing date
- 2020-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anxiety, Chronic breathlessness, depression, population survey, prevalence study
- in
- Journal of Pain and Symptom Management
- volume
- 59
- issue
- 2
- pages
- 2 - 205
- publisher
- Elsevier
- external identifiers
-
- scopus:85074539789
- pmid:31654741
- ISSN
- 0885-3924
- DOI
- 10.1016/j.jpainsymman.2019.09.021
- language
- English
- LU publication?
- yes
- id
- c686c5e9-7cc1-40d9-b94a-42f381ad5acb
- date added to LUP
- 2019-11-26 13:21:22
- date last changed
- 2024-06-27 08:48:47
@article{c686c5e9-7cc1-40d9-b94a-42f381ad5acb,
abstract = {{<p>Context: Breathlessness is associated with depression, but its relationship to anxiety or impaired function is less clear. Objectives: This study evaluated associations between chronic breathlessness and anxiety, depression, and functional status in the general population. Methods: This cross-sectional study of consenting adults (18 years and older) used an online survey. Quota sampling (n = 3000) was used reflecting the 2016 national census for sex, age, and place of residence. Other data included Four-Item Patient Health Questionnaire for depression and anxiety, the modified Medical Research Council (mMRC) Breathlessness Scale, and the Australia-modified Karnofsky Performance Scale. Multinomial logistic regression assessed predictors. Results: About 2977 respondents had all relevant scores (female 51.2%; median age 45.0 [range 18–92]). Prevalence of breathlessness (mMRC ≥2) was 2.4%, anxiety 6.0%, depression 2.7%, coexisting anxiety/depression 6.1%, and poorer functional status (Australia-modified Karnofsky Performance Scale ≤60) 1.6%. In multinomial regression, depression, anxiety, and coexisting anxiety/depression were predicted by younger age, longer duration of breathlessness, and poorer functional status. The highest proportions of people with breathlessness were found in the coexisting anxiety/depression group (10.6%) and depression only group (8.8%). Poorest function was in the coexisting anxiety/depression group with 11.6%. The relationship between poorer functional status and coexisting anxiety/depression was significant (odds ratio 0.90; 95% CI 0.89, 0.92). Adjusted odds ratio for breathlessness and depression only was 3.0 (95% CI 1.2, 7.8). Conclusion: Clinically important breathlessness (mMRC ≥2) was associated with depression, anxiety, and coexisting anxiety/depression. Poorer function that is associated with psychological morbidity in the general population requires further research.</p>}},
author = {{Currow, David C. and Chang, Sungwon and Reddel, Helen K. and Kochovska, Slavica and Ferreira, Diana and Kinchin, Irina and Johnson, Miriam and Ekström, Magnus}},
issn = {{0885-3924}},
keywords = {{anxiety; Chronic breathlessness; depression; population survey; prevalence study}},
language = {{eng}},
number = {{2}},
pages = {{2--205}},
publisher = {{Elsevier}},
series = {{Journal of Pain and Symptom Management}},
title = {{Breathlessness, Anxiety, Depression, and Function–The BAD-F Study : A Cross-Sectional and Population Prevalence Study in Adults}},
url = {{http://dx.doi.org/10.1016/j.jpainsymman.2019.09.021}},
doi = {{10.1016/j.jpainsymman.2019.09.021}},
volume = {{59}},
year = {{2020}},
}