Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes
(1988) In Scandinavian Journal of Clinical & Laboratory Investigation 48(6). p.553-556- Abstract (Swedish)
- Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/c7108776-9c28-46ac-9ddf-b56e759466c8
- author
- Jensen, Elmo ; Florén, Claes-Henrik LU and Nilsson, Åke LU
- publishing date
- 1988-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 48
- issue
- 6
- pages
- 4 pages
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:3217758
- scopus:0024097569
- ISSN
- 1502-7686
- DOI
- 10.3109/00365518809085772
- language
- English
- LU publication?
- no
- id
- c7108776-9c28-46ac-9ddf-b56e759466c8
- date added to LUP
- 2019-05-30 16:40:17
- date last changed
- 2021-11-30 04:03:41
@article{c7108776-9c28-46ac-9ddf-b56e759466c8, abstract = {{Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.}}, author = {{Jensen, Elmo and Florén, Claes-Henrik and Nilsson, Åke}}, issn = {{1502-7686}}, language = {{eng}}, month = {{10}}, number = {{6}}, pages = {{553--556}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical & Laboratory Investigation}}, title = {{Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes}}, url = {{http://dx.doi.org/10.3109/00365518809085772}}, doi = {{10.3109/00365518809085772}}, volume = {{48}}, year = {{1988}}, }