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Evaluation of renal function parameters with simultaneously administered 99mTc-DTPA and 131I-hippuran

Kempi, V. and Persson, B. R.R. LU orcid (1983) In European Journal Of Nuclear Medicine 8(2). p.65-71
Abstract

The present study aimed at comparing two renal function tests using 99mTc-DTPA (diethylene triamine penta acetic acid) and 131I-labeled hippuran (o-hippuric acid). A mixture of 80 Mbq 99mTc-DTPA and 7.4 MBq 131I-hippuran in a total volume of 1.5 ml or less was injected into an arm-vein. Both radiopharmaceuticals have identical intitial distributions in the blood pool when injected in this manner. Seventy-two patients were studied with the present dual radionuclide technique. The following parameters were derived from the renogram: area under curve, uptake ratio, Tmax, decrease ratio, excretion ratio, and rate of decrease. The parameters for 99mTc-DTPA and... (More)

The present study aimed at comparing two renal function tests using 99mTc-DTPA (diethylene triamine penta acetic acid) and 131I-labeled hippuran (o-hippuric acid). A mixture of 80 Mbq 99mTc-DTPA and 7.4 MBq 131I-hippuran in a total volume of 1.5 ml or less was injected into an arm-vein. Both radiopharmaceuticals have identical intitial distributions in the blood pool when injected in this manner. Seventy-two patients were studied with the present dual radionuclide technique. The following parameters were derived from the renogram: area under curve, uptake ratio, Tmax, decrease ratio, excretion ratio, and rate of decrease. The parameters for 99mTc-DTPA and 131I-hippuran were compared for various kidney groups. Generally the renographic parameters were well correlated. Apart from the systematic differences due to different modes of renal excretion, the curve patterns virtually agreed. The differences that were observed between the two tracers lacked clinical significance.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
in
European Journal Of Nuclear Medicine
volume
8
issue
2
pages
7 pages
publisher
Springer
external identifiers
  • scopus:0020538307
  • pmid:6341067
ISSN
0340-6997
DOI
10.1007/BF00252558
language
English
LU publication?
yes
id
c7eeb942-5903-4a22-8562-23883d398dba
date added to LUP
2020-05-07 21:29:31
date last changed
2025-01-10 12:43:26
@article{c7eeb942-5903-4a22-8562-23883d398dba,
  abstract     = {{<p>The present study aimed at comparing two renal function tests using <sup>99m</sup>Tc-DTPA (diethylene triamine penta acetic acid) and <sup>131</sup>I-labeled hippuran (o-hippuric acid). A mixture of 80 Mbq <sup>99m</sup>Tc-DTPA and 7.4 MBq <sup>131</sup>I-hippuran in a total volume of 1.5 ml or less was injected into an arm-vein. Both radiopharmaceuticals have identical intitial distributions in the blood pool when injected in this manner. Seventy-two patients were studied with the present dual radionuclide technique. The following parameters were derived from the renogram: area under curve, uptake ratio, T<sub>max</sub>, decrease ratio, excretion ratio, and rate of decrease. The parameters for <sup>99m</sup>Tc-DTPA and <sup>131</sup>I-hippuran were compared for various kidney groups. Generally the renographic parameters were well correlated. Apart from the systematic differences due to different modes of renal excretion, the curve patterns virtually agreed. The differences that were observed between the two tracers lacked clinical significance.</p>}},
  author       = {{Kempi, V. and Persson, B. R.R.}},
  issn         = {{0340-6997}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{65--71}},
  publisher    = {{Springer}},
  series       = {{European Journal Of Nuclear Medicine}},
  title        = {{Evaluation of renal function parameters with simultaneously administered <sup>99m</sup>Tc-DTPA and <sup>131</sup>I-hippuran}},
  url          = {{http://dx.doi.org/10.1007/BF00252558}},
  doi          = {{10.1007/BF00252558}},
  volume       = {{8}},
  year         = {{1983}},
}