The Archaeal Roots of the Eukaryotic Dynamic Actin Cytoskeleton
Stairs, Courtney W. LU
and Ettema, Thijs J.G.
(2020)
In Current Biology
30(10).
p.521-526
- Abstract
It is generally well accepted that eukaryotes evolved from the symbiosis of an archaeal host cell and an alphaproteobacterium, a union that ultimately gave rise to the complex, eukaryotic cells we see today. However, the catalyst of this merger, the exact nature of the cellular biology of either partner, or how this event spawned the vast majority of complex life on Earth remains enigmatic. In recent years, the discovery of the Asgard archaea, the closest known prokaryotic relatives of eukaryotes, has been monumental for addressing these unanswered questions. These prokaryotes seem to encode an unprecedented number of genes related to features typically descriptive of eukaryotes, including intracellular trafficking, vesicular transport... (More)
It is generally well accepted that eukaryotes evolved from the symbiosis of an archaeal host cell and an alphaproteobacterium, a union that ultimately gave rise to the complex, eukaryotic cells we see today. However, the catalyst of this merger, the exact nature of the cellular biology of either partner, or how this event spawned the vast majority of complex life on Earth remains enigmatic. In recent years, the discovery of the Asgard archaea, the closest known prokaryotic relatives of eukaryotes, has been monumental for addressing these unanswered questions. These prokaryotes seem to encode an unprecedented number of genes related to features typically descriptive of eukaryotes, including intracellular trafficking, vesicular transport and a dynamic actin-based cytoskeleton. Collectively, these features imply that the Asgard archaea have the potential for cellular complexity previously thought to be unique to eukaryotes. Here, we review the most recent advances in our understanding of the archaeal cytoskeleton and its implications for determining the origin of eukaryotic cellular complexity. The transition from prokaryotic to eukaryotic cells represents a cornerstone event in the evolution of life on Earth. The actin cytoskeleton is one of many key features of eukaryotic cells. Here, Stairs and Ettema review the most recent advances in our understanding of the archaeal cytoskeleton and its implications for the origins of eukaryotes.
(Less)
- author
- Stairs, Courtney W.
LU
and Ettema, Thijs J.G.
- publishing date
- 2020-05-18
- type
- Contribution to journal
- publication status
- published
- in
- Current Biology
- volume
- 30
- issue
- 10
- pages
- 521 - 526
- publisher
- Elsevier
- external identifiers
-
- pmid:32428493
- scopus:85084561748
- ISSN
- 0960-9822
- DOI
- 10.1016/j.cub.2020.02.074
- language
- English
- LU publication?
- no
- id
- c9bce1f9-ef20-4288-af55-3750f458fb8f
- date added to LUP
- 2020-10-23 10:46:45
- date last changed
- 2024-06-26 23:28:11
@article{c9bce1f9-ef20-4288-af55-3750f458fb8f,
abstract = {{<p>It is generally well accepted that eukaryotes evolved from the symbiosis of an archaeal host cell and an alphaproteobacterium, a union that ultimately gave rise to the complex, eukaryotic cells we see today. However, the catalyst of this merger, the exact nature of the cellular biology of either partner, or how this event spawned the vast majority of complex life on Earth remains enigmatic. In recent years, the discovery of the Asgard archaea, the closest known prokaryotic relatives of eukaryotes, has been monumental for addressing these unanswered questions. These prokaryotes seem to encode an unprecedented number of genes related to features typically descriptive of eukaryotes, including intracellular trafficking, vesicular transport and a dynamic actin-based cytoskeleton. Collectively, these features imply that the Asgard archaea have the potential for cellular complexity previously thought to be unique to eukaryotes. Here, we review the most recent advances in our understanding of the archaeal cytoskeleton and its implications for determining the origin of eukaryotic cellular complexity. The transition from prokaryotic to eukaryotic cells represents a cornerstone event in the evolution of life on Earth. The actin cytoskeleton is one of many key features of eukaryotic cells. Here, Stairs and Ettema review the most recent advances in our understanding of the archaeal cytoskeleton and its implications for the origins of eukaryotes.</p>}},
author = {{Stairs, Courtney W. and Ettema, Thijs J.G.}},
issn = {{0960-9822}},
language = {{eng}},
month = {{05}},
number = {{10}},
pages = {{521--526}},
publisher = {{Elsevier}},
series = {{Current Biology}},
title = {{The Archaeal Roots of the Eukaryotic Dynamic Actin Cytoskeleton}},
url = {{http://dx.doi.org/10.1016/j.cub.2020.02.074}},
doi = {{10.1016/j.cub.2020.02.074}},
volume = {{30}},
year = {{2020}},
}