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Serum concentration/dose ratio of levetiracetam before, during and after pregnancy

Westin, Andreas Austgulen ; Reimers, Arne LU orcid ; Helde, Grethe ; Nakken, Karl Otto and Brodtkorb, Eylert (2008) In Seizure 17(2). p.192-198
Abstract

Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p < 0.001, n = 11).... (More)

Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p < 0.001, n = 11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced. Conclusions: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Clearance, Elimination, Epilepsy, Levetiracetam, Pharmacokinetics, Pregnancy
in
Seizure
volume
17
issue
2
pages
192 - 198
publisher
Elsevier
external identifiers
  • scopus:38949134810
  • pmid:18180176
ISSN
1059-1311
DOI
10.1016/j.seizure.2007.11.027
language
English
LU publication?
no
id
cab6b701-b129-458b-aa1c-4b90d5ced849
date added to LUP
2024-08-31 14:56:53
date last changed
2025-10-14 11:16:01
@article{cab6b701-b129-458b-aa1c-4b90d5ced849,
  abstract     = {{<p>Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p &lt; 0.001, n = 11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced. Conclusions: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.</p>}},
  author       = {{Westin, Andreas Austgulen and Reimers, Arne and Helde, Grethe and Nakken, Karl Otto and Brodtkorb, Eylert}},
  issn         = {{1059-1311}},
  keywords     = {{Clearance; Elimination; Epilepsy; Levetiracetam; Pharmacokinetics; Pregnancy}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{192--198}},
  publisher    = {{Elsevier}},
  series       = {{Seizure}},
  title        = {{Serum concentration/dose ratio of levetiracetam before, during and after pregnancy}},
  url          = {{http://dx.doi.org/10.1016/j.seizure.2007.11.027}},
  doi          = {{10.1016/j.seizure.2007.11.027}},
  volume       = {{17}},
  year         = {{2008}},
}