Serum concentration/dose ratio of levetiracetam before, during and after pregnancy
(2008) In Seizure 17(2). p.192-198- Abstract
Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p < 0.001, n = 11).... (More)
Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p < 0.001, n = 11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced. Conclusions: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.
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- author
- Westin, Andreas Austgulen ; Reimers, Arne LU ; Helde, Grethe ; Nakken, Karl Otto and Brodtkorb, Eylert
- publishing date
- 2008-03
- type
- Contribution to journal
- publication status
- published
- keywords
- Clearance, Elimination, Epilepsy, Levetiracetam, Pharmacokinetics, Pregnancy
- in
- Seizure
- volume
- 17
- issue
- 2
- pages
- 192 - 198
- publisher
- Elsevier
- external identifiers
-
- pmid:18180176
- scopus:38949134810
- ISSN
- 1059-1311
- DOI
- 10.1016/j.seizure.2007.11.027
- language
- English
- LU publication?
- no
- id
- cab6b701-b129-458b-aa1c-4b90d5ced849
- date added to LUP
- 2024-08-31 14:56:53
- date last changed
- 2024-09-05 08:36:24
@article{cab6b701-b129-458b-aa1c-4b90d5ced849, abstract = {{<p>Purpose: To investigate changes in levetiracetam (LEV) serum concentration/dose ratio (C/D-ratio) in relation to pregnancy. Methods: Altogether 21 consecutive pregnancies in 20 women with epilepsy receiving LEV during gestation were studied retrospectively. The main target variable was the C/D-ratio before and during pregnancy, and in the post partum period. Secondary target variables were changes in LEV dose, concomitant use of other antiepileptic drugs and seizure frequency. Student's paired t-test and two-sample t-test for independent samples were used to test for statistically significant changes in C/D-ratio means. Results: Mean C/D-ratio in the third trimester was 50% of the mean C/D-ratio at baseline (p < 0.001, n = 11). Baseline levels were reached within the first weeks after pregnancy. The interindividual variability was pronounced. Conclusions: Serum concentrations of LEV declined significantly in the third trimester of pregnancy and increased rapidly after delivery.</p>}}, author = {{Westin, Andreas Austgulen and Reimers, Arne and Helde, Grethe and Nakken, Karl Otto and Brodtkorb, Eylert}}, issn = {{1059-1311}}, keywords = {{Clearance; Elimination; Epilepsy; Levetiracetam; Pharmacokinetics; Pregnancy}}, language = {{eng}}, number = {{2}}, pages = {{192--198}}, publisher = {{Elsevier}}, series = {{Seizure}}, title = {{Serum concentration/dose ratio of levetiracetam before, during and after pregnancy}}, url = {{http://dx.doi.org/10.1016/j.seizure.2007.11.027}}, doi = {{10.1016/j.seizure.2007.11.027}}, volume = {{17}}, year = {{2008}}, }