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Spontaneous Self-Assembly of Thermoresponsive Vesicles Using a Zwitterionic and an Anionic Surfactant

McCoy, Thomas M. ; Marlow, Joshua B. ; Armstrong, Alexander J. ; Clulow, Andrew J. ; Garvey, Christopher J. LU orcid ; Manohar, Madhura ; Darwish, Tamim A. ; Boyd, Ben J. ; Routh, Alexander F. and Tabor, Rico F. (2020) In Biomacromolecules 21(11). p.4569-4576
Abstract

Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical micelles or mixtures of micellar structures, and salt concentration, whereby increasing the amount of NaCl promotes vesicle formation by reducing headgroup repulsions. Small-angle neutron scattering measurements reveal that the vesicles are approximately 30-40 nm in diameter, depending on sample composition. Small-angle X-ray scattering... (More)

Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical micelles or mixtures of micellar structures, and salt concentration, whereby increasing the amount of NaCl promotes vesicle formation by reducing headgroup repulsions. Small-angle neutron scattering measurements reveal that the vesicles are approximately 30-40 nm in diameter, depending on sample composition. Small-angle X-ray scattering measurements suggest preferential partitioning of OAPB molecules on the vesicle inner layer to support vesicular packing. Heating the vesicles to physiological temperature (37 °C) causes them to collapse into smaller ellipsoidal micelles (2-3 nm), with higher salt concentrations (≥10 mM) inhibiting this transition. These aggregates could serve as responsive carriers for loading or unloading of aqueous cargoes such as drugs and pharmaceuticals, with temperature changes serving as a simple release/uptake mechanism.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomacromolecules
volume
21
issue
11
pages
8 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:32597638
  • scopus:85095861687
ISSN
1526-4602
DOI
10.1021/acs.biomac.0c00672
language
English
LU publication?
yes
id
cb1f6323-f945-4e45-af14-203999867a5d
date added to LUP
2020-11-24 14:35:46
date last changed
2024-05-16 21:49:45
@article{cb1f6323-f945-4e45-af14-203999867a5d,
  abstract     = {{<p>Spontaneous formation of vesicles from the self-assembly of two specific surfactants, one zwitterionic (oleyl amidopropyl betaine, OAPB) and the other anionic (Aerosol-OT, AOT), is explored in water using small-angle scattering techniques. Two factors were found to be critical in the formation of vesicles: surfactant ratio, as AOT concentrations less than equimolar with OAPB result in cylindrical micelles or mixtures of micellar structures, and salt concentration, whereby increasing the amount of NaCl promotes vesicle formation by reducing headgroup repulsions. Small-angle neutron scattering measurements reveal that the vesicles are approximately 30-40 nm in diameter, depending on sample composition. Small-angle X-ray scattering measurements suggest preferential partitioning of OAPB molecules on the vesicle inner layer to support vesicular packing. Heating the vesicles to physiological temperature (37 °C) causes them to collapse into smaller ellipsoidal micelles (2-3 nm), with higher salt concentrations (≥10 mM) inhibiting this transition. These aggregates could serve as responsive carriers for loading or unloading of aqueous cargoes such as drugs and pharmaceuticals, with temperature changes serving as a simple release/uptake mechanism.</p>}},
  author       = {{McCoy, Thomas M. and Marlow, Joshua B. and Armstrong, Alexander J. and Clulow, Andrew J. and Garvey, Christopher J. and Manohar, Madhura and Darwish, Tamim A. and Boyd, Ben J. and Routh, Alexander F. and Tabor, Rico F.}},
  issn         = {{1526-4602}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{4569--4576}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Biomacromolecules}},
  title        = {{Spontaneous Self-Assembly of Thermoresponsive Vesicles Using a Zwitterionic and an Anionic Surfactant}},
  url          = {{http://dx.doi.org/10.1021/acs.biomac.0c00672}},
  doi          = {{10.1021/acs.biomac.0c00672}},
  volume       = {{21}},
  year         = {{2020}},
}