Cell-based cartilage repair : Do we need it, can we do it, is it good, can we prove it?
Stefan Lohmander, L. LU
(1998)
In Current Opinion in Orthopaedics
9(6).
p.38-42
- Abstract
Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and other methods. Animal model work and preliminary experience in humans suggest that some degree of cartilage repair can be accomplished with these methods. However, the long-term fate of the transplants, and the benefits are still uncertain. No randomized, controlled and blinded trials have been presented, and available data do not support any... (More)
Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and other methods. Animal model work and preliminary experience in humans suggest that some degree of cartilage repair can be accomplished with these methods. However, the long-term fate of the transplants, and the benefits are still uncertain. No randomized, controlled and blinded trials have been presented, and available data do not support any certain conclusions with regard to the superiority of one method of cartilage repair over the other, or indeed over treatment without surgery. Better understanding of the role of morphogens, growth factors, stem cells, cartilage development and biology, and tissue engineering may allow the development of improved therapy. Treatment with these experimental methods should only lie done within the context of strictly designed randomized, controlled and masked clinical trials with several years of follow-up time.
(Less)
- author
- Stefan Lohmander, L.
LU
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- in
- Current Opinion in Orthopaedics
- volume
- 9
- issue
- 6
- pages
- 5 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0032465510
- ISSN
- 1041-9918
- language
- English
- LU publication?
- no
- id
- cc664b8a-4c6a-4a2d-a2b4-2604c240580e
- date added to LUP
- 2016-05-04 23:58:59
- date last changed
- 2023-02-16 01:51:33
@article{cc664b8a-4c6a-4a2d-a2b4-2604c240580e,
abstract = {{<p>Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and other methods. Animal model work and preliminary experience in humans suggest that some degree of cartilage repair can be accomplished with these methods. However, the long-term fate of the transplants, and the benefits are still uncertain. No randomized, controlled and blinded trials have been presented, and available data do not support any certain conclusions with regard to the superiority of one method of cartilage repair over the other, or indeed over treatment without surgery. Better understanding of the role of morphogens, growth factors, stem cells, cartilage development and biology, and tissue engineering may allow the development of improved therapy. Treatment with these experimental methods should only lie done within the context of strictly designed randomized, controlled and masked clinical trials with several years of follow-up time.</p>}},
author = {{Stefan Lohmander, L.}},
issn = {{1041-9918}},
language = {{eng}},
number = {{6}},
pages = {{38--42}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Orthopaedics}},
title = {{Cell-based cartilage repair : Do we need it, can we do it, is it good, can we prove it?}},
volume = {{9}},
year = {{1998}},
}