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Adiponectin as a predictor of mortality and readmission in patients with community-acquired pneumonia : a prospective cohort study

Dungu, Arnold Matovu ; Ryrsø, Camilla Koch ; Hegelund, Maria Hein ; Sejdic, Adin LU ; Jensen, Andreas Vestergaard ; Kristensen, Peter Lommer ; Krogh-Madsen, Rikke ; Faurholt-Jepsen, Daniel and Lindegaard, Birgitte (2024) In Frontiers in Medicine 11.
Abstract

BACKGROUND: Adiponectin is secreted by adipocytes and is inversely associated with obesity. Given the association between low body mass index (BMI) and higher mortality risk after community-acquired pneumonia (CAP), we hypothesized that high adiponectin levels are associated with a higher risk of adverse clinical outcomes in patients with CAP.

METHODS: In a prospective cohort study of 502 patients hospitalized with CAP, adiponectin was measured in serum at admission. The associations between adiponectin and clinical outcomes were estimated with logistic regression analyses adjusted for age, sex, and measures of obesity (BMI, waist circumference or body fat percentage).

RESULTS: Adiponectin was associated with higher 90-day... (More)

BACKGROUND: Adiponectin is secreted by adipocytes and is inversely associated with obesity. Given the association between low body mass index (BMI) and higher mortality risk after community-acquired pneumonia (CAP), we hypothesized that high adiponectin levels are associated with a higher risk of adverse clinical outcomes in patients with CAP.

METHODS: In a prospective cohort study of 502 patients hospitalized with CAP, adiponectin was measured in serum at admission. The associations between adiponectin and clinical outcomes were estimated with logistic regression analyses adjusted for age, sex, and measures of obesity (BMI, waist circumference or body fat percentage).

RESULTS: Adiponectin was associated with higher 90-day mortality for each 1 μg/mL increase [OR 1.02, 95% CI (1.00, 1.04), p = 0.048] independent of age and sex. Likewise, adiponectin was associated with a higher risk of 90-day readmission for each 1 μg/mL increase [OR 1.02, 95% CI (1.01, 1.04), p = 0.007] independent of age and sex. The association between adiponectin and 90-day mortality disappeared, while the association with 90-day readmission remained after adjusting for adiposity.

CONCLUSION: Adiponectin was positively associated with mortality and readmission. The association with mortality depended on low body fat, whereas the association with readmission risk was independent of obesity.

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author
; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Medicine
volume
11
article number
1329417
publisher
Frontiers Media S. A.
external identifiers
  • pmid:38633314
  • scopus:85190366577
ISSN
2296-858X
DOI
10.3389/fmed.2024.1329417
language
English
LU publication?
no
additional info
Copyright © 2024 Dungu, Ryrsø, Hegelund, Sejdic, Jensen, Kristensen, Krogh-Madsen, Faurholt-Jepsen and Lindegaard.
id
ceeeae96-4437-4767-a3ca-b401e28046cc
date added to LUP
2024-10-14 09:18:48
date last changed
2025-07-09 02:28:57
@article{ceeeae96-4437-4767-a3ca-b401e28046cc,
  abstract     = {{<p>BACKGROUND: Adiponectin is secreted by adipocytes and is inversely associated with obesity. Given the association between low body mass index (BMI) and higher mortality risk after community-acquired pneumonia (CAP), we hypothesized that high adiponectin levels are associated with a higher risk of adverse clinical outcomes in patients with CAP.</p><p>METHODS: In a prospective cohort study of 502 patients hospitalized with CAP, adiponectin was measured in serum at admission. The associations between adiponectin and clinical outcomes were estimated with logistic regression analyses adjusted for age, sex, and measures of obesity (BMI, waist circumference or body fat percentage).</p><p>RESULTS: Adiponectin was associated with higher 90-day mortality for each 1 μg/mL increase [OR 1.02, 95% CI (1.00, 1.04), p = 0.048] independent of age and sex. Likewise, adiponectin was associated with a higher risk of 90-day readmission for each 1 μg/mL increase [OR 1.02, 95% CI (1.01, 1.04), p = 0.007] independent of age and sex. The association between adiponectin and 90-day mortality disappeared, while the association with 90-day readmission remained after adjusting for adiposity.</p><p>CONCLUSION: Adiponectin was positively associated with mortality and readmission. The association with mortality depended on low body fat, whereas the association with readmission risk was independent of obesity.</p>}},
  author       = {{Dungu, Arnold Matovu and Ryrsø, Camilla Koch and Hegelund, Maria Hein and Sejdic, Adin and Jensen, Andreas Vestergaard and Kristensen, Peter Lommer and Krogh-Madsen, Rikke and Faurholt-Jepsen, Daniel and Lindegaard, Birgitte}},
  issn         = {{2296-858X}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Medicine}},
  title        = {{Adiponectin as a predictor of mortality and readmission in patients with community-acquired pneumonia : a prospective cohort study}},
  url          = {{http://dx.doi.org/10.3389/fmed.2024.1329417}},
  doi          = {{10.3389/fmed.2024.1329417}},
  volume       = {{11}},
  year         = {{2024}},
}