Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies
Hazer, Derya Burcu LU
; Hazer, Baki
and Kaymaz, Figen
(2009)
In Biomedical materials
4(3).
- Abstract
Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PHO-Sy-2080, PHO-Sy-2872 and PHO-Sy-5050, respectively. The PHA films were obtained by solvent cast from CHCl3. They were all originally sticky and waxy except PHO-Sy-5050. Autoxidation of the unsaturated copolyester films was carried out on exposure to air at room temperature in order to obtain crosslinked polymers. They became a... (More)
Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PHO-Sy-2080, PHO-Sy-2872 and PHO-Sy-5050, respectively. The PHA films were obtained by solvent cast from CHCl3. They were all originally sticky and waxy except PHO-Sy-5050. Autoxidation of the unsaturated copolyester films was carried out on exposure to air at room temperature in order to obtain crosslinked polymers. They became a highly flexible elastomer after being autoxidized (about 40 days of autoxidation). The in vivo tissue reactions of the autoxidized PHAs were evaluated by subcutaneous implantation in rats. The rats appeared to be healthy throughout the implantation period. No symptom such as necrosis, abscess or tumorigenesis was observed in the vicinity of the implants. Retrieved materials varied in their physical appearance after 6 weeks of implantation. In vivo biocompatibility studies of the medical applications indicated that the microbial copolyesters obtained were all biocompatible and especially the PHOSy series of copolyesters had the highest biocompatibility among them.
(Less)
- author
- Hazer, Derya Burcu
LU
; Hazer, Baki
and Kaymaz, Figen
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- in
- Biomedical materials
- volume
- 4
- issue
- 3
- article number
- 035011
- publisher
- IOP Publishing
- external identifiers
-
- scopus:68249152492
- pmid:19498224
- ISSN
- 1748-6041
- DOI
- 10.1088/1748-6041/4/3/035011
- language
- English
- LU publication?
- no
- id
- d224569c-4d10-4cb5-8f35-c80cdff57f5e
- date added to LUP
- 2025-05-11 22:44:01
- date last changed
- 2025-05-13 03:16:30
@article{d224569c-4d10-4cb5-8f35-c80cdff57f5e,
abstract = {{<p>Biocompatibility studies of the autoxidized and unoxidized unsaturated medium-long chain length (m-lcl) co-poly-3-hydroxyalkanoates (m-lclPHAs) derived from soya oily acids have been reported. Pseudomonas oleovorans was grown on a series of mixtures of octanoic acid (OA) and soya oily acids (Sy) with weight ratios of 20:80, 28:72 and 50:50 in order to obtain unsaturated m-lcl copolyesters coded PHO-Sy-2080, PHO-Sy-2872 and PHO-Sy-5050, respectively. The PHA films were obtained by solvent cast from CHCl<sub>3</sub>. They were all originally sticky and waxy except PHO-Sy-5050. Autoxidation of the unsaturated copolyester films was carried out on exposure to air at room temperature in order to obtain crosslinked polymers. They became a highly flexible elastomer after being autoxidized (about 40 days of autoxidation). The in vivo tissue reactions of the autoxidized PHAs were evaluated by subcutaneous implantation in rats. The rats appeared to be healthy throughout the implantation period. No symptom such as necrosis, abscess or tumorigenesis was observed in the vicinity of the implants. Retrieved materials varied in their physical appearance after 6 weeks of implantation. In vivo biocompatibility studies of the medical applications indicated that the microbial copolyesters obtained were all biocompatible and especially the PHOSy series of copolyesters had the highest biocompatibility among them.</p>}},
author = {{Hazer, Derya Burcu and Hazer, Baki and Kaymaz, Figen}},
issn = {{1748-6041}},
language = {{eng}},
number = {{3}},
publisher = {{IOP Publishing}},
series = {{Biomedical materials}},
title = {{Synthesis of microbial elastomers based on soybean oily acids. Biocompatibility studies}},
url = {{http://dx.doi.org/10.1088/1748-6041/4/3/035011}},
doi = {{10.1088/1748-6041/4/3/035011}},
volume = {{4}},
year = {{2009}},
}