High antibiotic susceptibility among bacterial pathogens in Swedish ICUs
(2004) In Scandinavian Journal of Infectious Diseases 36(1). p.24-30- Abstract
Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were defined as treatment alternatives (TA90). The mean number of TA90 was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU),... (More)
Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD1000). Antibiotics to which >90% of isolates of an organism were susceptible were defined as treatment alternatives (TA90). The mean number of TA90 was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU), but higher (3-7) for Acinetobacter spp. (imipenem:IMI, NET, TSU), Enterococcus faecalis (ampicillin:AMP, IMI, VAN), Serratia spp. (ciprofloxacin:CIP, IMI, NET), Enterobacter spp. (CIP, IMI, NET, TSU), E. coli (cefuroxime:CXM, cefotaxime/ceftazidime:CTX/CTZ, CIP, IMI, NET, piperacillin-tazobactam:PTZ, TSU), Klebsiella spp. (CTX/CTZ CIP, IMI, NET, PTZ, TSU) and Staphylococcus aureus (clindamycin, fusidic acid, NET, oxacillin, rifampicin, VAN). Of S. aureus isolates 2% were MRSA. Facilities for alcohol hand disinfection at each bed were available in 96% of the ICUs. The numbers of TA90 available were apparently higher than in ICUs in southern Europe and the US, despite a relatively high antibiotic consumption. This may be due to a moderate ecological impact of the used agents and the infection control routines in Swedish ICUs.
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- author
- Hanberger, Håkan ; Erlandsson, Marcus LU ; Burman, Lars G. ; Cars, Otto ; Gill, Hans ; Lindgren, Sune ; Nilsson, Lennart E. ; Olsson-Liljequist, Barbro and Walther, Sten
- author collaboration
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Infectious Diseases
- volume
- 36
- issue
- 1
- pages
- 24 - 30
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:1242296972
- pmid:15000555
- ISSN
- 0036-5548
- DOI
- 10.1080/00365540310017429
- language
- English
- LU publication?
- no
- id
- d56f54a8-849c-48c7-a641-2fa6babbe5c1
- date added to LUP
- 2020-04-16 12:09:14
- date last changed
- 2024-08-08 18:43:46
@article{d56f54a8-849c-48c7-a641-2fa6babbe5c1, abstract = {{<p>Local infection control measures, antibiotic consumption and patient demographics from 1999-2000 together with bacteriological analyses were investigated in 29 ICUs participating in the ICU-STRAMA programme. The median antibiotic consumption per ICU was 1147 (range 605-2143) daily doses per 1000 occupied bed d (DDD<sub>1000</sub>). Antibiotics to which >90% of isolates of an organism were susceptible were defined as treatment alternatives (TA<sub>90</sub>). The mean number of TA<sub>90</sub> was low (1-2 per organism) for Enterococcus faecium (vancomycin:VAN), coagulase negative staphylococci (VAN), Pseudomonas aeruginosa (ceftazidime:CTZ, netilmicin: NET) and Stenotrophomonas maltophilia (CTZ, trimethoprim-sulfamethoxazole: TSU), but higher (3-7) for Acinetobacter spp. (imipenem:IMI, NET, TSU), Enterococcus faecalis (ampicillin:AMP, IMI, VAN), Serratia spp. (ciprofloxacin:CIP, IMI, NET), Enterobacter spp. (CIP, IMI, NET, TSU), E. coli (cefuroxime:CXM, cefotaxime/ceftazidime:CTX/CTZ, CIP, IMI, NET, piperacillin-tazobactam:PTZ, TSU), Klebsiella spp. (CTX/CTZ CIP, IMI, NET, PTZ, TSU) and Staphylococcus aureus (clindamycin, fusidic acid, NET, oxacillin, rifampicin, VAN). Of S. aureus isolates 2% were MRSA. Facilities for alcohol hand disinfection at each bed were available in 96% of the ICUs. The numbers of TA<sub>90</sub> available were apparently higher than in ICUs in southern Europe and the US, despite a relatively high antibiotic consumption. This may be due to a moderate ecological impact of the used agents and the infection control routines in Swedish ICUs.</p>}}, author = {{Hanberger, Håkan and Erlandsson, Marcus and Burman, Lars G. and Cars, Otto and Gill, Hans and Lindgren, Sune and Nilsson, Lennart E. and Olsson-Liljequist, Barbro and Walther, Sten}}, issn = {{0036-5548}}, language = {{eng}}, number = {{1}}, pages = {{24--30}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Infectious Diseases}}, title = {{High antibiotic susceptibility among bacterial pathogens in Swedish ICUs}}, url = {{http://dx.doi.org/10.1080/00365540310017429}}, doi = {{10.1080/00365540310017429}}, volume = {{36}}, year = {{2004}}, }