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Understanding inhomogeneous MT (ihMT) in multi-parameter mapping of human brain: Towards larger ihMT, higher resolution, and influence of T1d

Helms, Gunther LU orcid ; Vaculčiaková, Lenka ; Pine, Kerrin J ; Möller, Harald E and Weiskopf, Nikolaus (2022) In Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition 30.
Abstract
Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is more complex than MT approaches. Expressing ihMT in terms of MT-saturation (ihMTsat) is a first step to quantification as it corrects for underlying T and B . Larger ihMTsat was observed for smaller frequency offsets, which is explained using MTsat as proxy for bound pool saturation. For longer TR, ihMTsat increased faster than MTsat indicating recovery of dipolar order as ihMTsat increased super-linearly to 1.1pu in WM and 0.2pu in GM at TR=52ms. ihMTsat mapping in vivo was performed at 1.3mm isotropic resolution.
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type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition
series title
Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition
volume
30
article number
2705
publisher
International Society for Magnetic Resonance in Medicine
ISSN
1545-4428
language
English
LU publication?
yes
id
d6788134-ad32-4b15-bbb9-d52dace57ab0
alternative location
https://index.mirasmart.com/ISMRM2022/PDFfiles/2705.html
date added to LUP
2022-07-13 12:41:22
date last changed
2022-11-29 08:07:29
@inproceedings{d6788134-ad32-4b15-bbb9-d52dace57ab0,
  abstract     = {{Inhomogenous Magnetization Transfer (ihMT), the differential response to irradiation at single and dual frequency offsets, is more complex than MT approaches. Expressing ihMT in terms of MT-saturation (ihMTsat) is a first step to quantification as it corrects for underlying T and B . Larger ihMTsat was observed for smaller frequency offsets, which is explained using MTsat as proxy for bound pool saturation. For longer TR, ihMTsat increased faster than MTsat indicating recovery of dipolar order as ihMTsat increased super-linearly to 1.1pu in WM and 0.2pu in GM at TR=52ms. ihMTsat mapping in vivo was performed at 1.3mm isotropic resolution.}},
  author       = {{Helms, Gunther and Vaculčiaková, Lenka and Pine, Kerrin J and Möller, Harald E and Weiskopf, Nikolaus}},
  booktitle    = {{Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition}},
  issn         = {{1545-4428}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{International Society for Magnetic Resonance in Medicine}},
  series       = {{Proceedings of the 2022 ISMRM & ISMRT Annual Meeting and Exhibition}},
  title        = {{Understanding inhomogeneous MT (ihMT) in multi-parameter mapping of human brain: Towards larger ihMT, higher resolution, and influence of T<sub>1d</sub>}},
  url          = {{https://index.mirasmart.com/ISMRM2022/PDFfiles/2705.html}},
  volume       = {{30}},
  year         = {{2022}},
}