Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

(G)Patching up mis-splicing in cancer

Cieśla, Maciej and Bellodi, Cristian LU (2024) In Trends in Biochemical Sciences 49(7). p.564-566
Abstract

Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.

Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
DHX15, G-patch domain, GPATCH8, SF3B1, splicing, SUGP1
in
Trends in Biochemical Sciences
volume
49
issue
7
pages
3 pages
publisher
Elsevier
external identifiers
  • scopus:85194135286
  • pmid:38762373
ISSN
0968-0004
DOI
10.1016/j.tibs.2024.05.001
language
English
LU publication?
yes
id
d8cf594b-2d44-4739-bfff-97a470f99711
date added to LUP
2025-01-09 11:59:08
date last changed
2025-07-11 03:16:12
@article{d8cf594b-2d44-4739-bfff-97a470f99711,
  abstract     = {{<p>Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.</p>}},
  author       = {{Cieśla, Maciej and Bellodi, Cristian}},
  issn         = {{0968-0004}},
  keywords     = {{DHX15; G-patch domain; GPATCH8; SF3B1; splicing; SUGP1}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{564--566}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Biochemical Sciences}},
  title        = {{(G)Patching up mis-splicing in cancer}},
  url          = {{http://dx.doi.org/10.1016/j.tibs.2024.05.001}},
  doi          = {{10.1016/j.tibs.2024.05.001}},
  volume       = {{49}},
  year         = {{2024}},
}