Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk : The JPHC Study
(2016) In Scientific Reports 6.- Abstract
The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide polymorphisms (SNPs) in two pathways related to alcohol intake. 375 cases of CRC were identified among 38 373 Japan Public Health Center-based prospective Study (JPHC Study) participants who had returned a baseline questionnaire, reported no diagnosis of any cancer and provided blood samples. For each case, two controls were selected on matching variables. Logistic regression models were used to determine matched Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between alcohol consumption, genetic polymorphisms of enzymes in the alcohol- and folate metabolic pathways (e.g. methylenetetrahydrofolate reductase... (More)
The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide polymorphisms (SNPs) in two pathways related to alcohol intake. 375 cases of CRC were identified among 38 373 Japan Public Health Center-based prospective Study (JPHC Study) participants who had returned a baseline questionnaire, reported no diagnosis of any cancer and provided blood samples. For each case, two controls were selected on matching variables. Logistic regression models were used to determine matched Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between alcohol consumption, genetic polymorphisms of enzymes in the alcohol- and folate metabolic pathways (e.g. methylenetetrahydrofolate reductase (MTHFR) rs1801133) and CRC risk. Compared to never/occasional alcohol intake, moderate to heavy alcohol intake was associated with CRC (OR = 2.12, 95% CI, 1.34-3.36). When compared to the CC genotype, the MTHFR rs1801133 CT/TT genotype was inversely associated with CRC (OR = 0.72, 95% CI, 0.54-0.97). Never/occasional consumers of alcohol with the MTHFR rs1801133 CT/TT genotype were also at a reduced risk of CRC compared to never/occasional drinkers with the CC genotype (OR = 0.68, 95% CI, 0.47-0.98) (P for interaction = 0.27). The results indicate that the folate pathway is likely to be involved in alcohol-related CRC development.
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- author
- Svensson, Thomas LU ; Yamaji, Taiki ; Budhathoki, Sanjeev ; Hidaka, Akihisa ; Iwasaki, Motoki ; Sawada, Norie ; Inoue, Manami ; Sasazuki, Shizuka ; Shimazu, Taichi and Tsugane, Shoichiro
- publishing date
- 2016-11-09
- type
- Contribution to journal
- publication status
- published
- in
- Scientific Reports
- volume
- 6
- article number
- 36607
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:27827401
- scopus:84994504480
- ISSN
- 2045-2322
- DOI
- 10.1038/srep36607
- language
- English
- LU publication?
- no
- id
- d98c92a2-73ea-43e7-b976-5696daa7ad72
- date added to LUP
- 2017-05-11 07:23:36
- date last changed
- 2024-10-14 05:57:51
@article{d98c92a2-73ea-43e7-b976-5696daa7ad72, abstract = {{<p>The association between alcohol intake and colorectal cancer (CRC) may vary secondary to single nucleotide polymorphisms (SNPs) in two pathways related to alcohol intake. 375 cases of CRC were identified among 38 373 Japan Public Health Center-based prospective Study (JPHC Study) participants who had returned a baseline questionnaire, reported no diagnosis of any cancer and provided blood samples. For each case, two controls were selected on matching variables. Logistic regression models were used to determine matched Odds Ratios (OR) and 95% Confidence Intervals (CI) for the association between alcohol consumption, genetic polymorphisms of enzymes in the alcohol- and folate metabolic pathways (e.g. methylenetetrahydrofolate reductase (MTHFR) rs1801133) and CRC risk. Compared to never/occasional alcohol intake, moderate to heavy alcohol intake was associated with CRC (OR = 2.12, 95% CI, 1.34-3.36). When compared to the CC genotype, the MTHFR rs1801133 CT/TT genotype was inversely associated with CRC (OR = 0.72, 95% CI, 0.54-0.97). Never/occasional consumers of alcohol with the MTHFR rs1801133 CT/TT genotype were also at a reduced risk of CRC compared to never/occasional drinkers with the CC genotype (OR = 0.68, 95% CI, 0.47-0.98) (P for interaction = 0.27). The results indicate that the folate pathway is likely to be involved in alcohol-related CRC development.</p>}}, author = {{Svensson, Thomas and Yamaji, Taiki and Budhathoki, Sanjeev and Hidaka, Akihisa and Iwasaki, Motoki and Sawada, Norie and Inoue, Manami and Sasazuki, Shizuka and Shimazu, Taichi and Tsugane, Shoichiro}}, issn = {{2045-2322}}, language = {{eng}}, month = {{11}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk : The JPHC Study}}, url = {{http://dx.doi.org/10.1038/srep36607}}, doi = {{10.1038/srep36607}}, volume = {{6}}, year = {{2016}}, }