Familial hypercholesterolaemia : cholesterol efflux and coronary disease
(2016) In European Journal of Clinical Investigation 46(7). p.643-650- Abstract
Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the... (More)
Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.
(Less)
- author
- organization
- publishing date
- 2016-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apolipoprotein M, cholesterol efflux, familial hypercholesterolaemia, high-density lipoprotein, sphingolipids, sphingosine-phosphate
- in
- European Journal of Clinical Investigation
- volume
- 46
- issue
- 7
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:27208892
- scopus:84976595523
- ISSN
- 0014-2972
- DOI
- 10.1111/eci.12643
- language
- English
- LU publication?
- yes
- id
- dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae
- date added to LUP
- 2017-01-24 12:40:10
- date last changed
- 2024-07-14 02:56:08
@article{dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae, abstract = {{<p>Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.</p>}}, author = {{Versmissen, Jorie and Vongpromek, Ranitha and Yahya, Reyhana and van der Net, Jeroen B. and van Vark-van der Zee, Leonie and Blommesteijn-Touw, Jeannette and Wattimena, Darcos and Rietveld, Trinet and Pullinger, Clive R. and Christoffersen, Christina and Dahlbäck, Björn and Kane, John P. and Mulder, Monique and Sijbrands, Eric J G}}, issn = {{0014-2972}}, keywords = {{Apolipoprotein M; cholesterol efflux; familial hypercholesterolaemia; high-density lipoprotein; sphingolipids; sphingosine-phosphate}}, language = {{eng}}, month = {{07}}, number = {{7}}, pages = {{643--650}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Clinical Investigation}}, title = {{Familial hypercholesterolaemia : cholesterol efflux and coronary disease}}, url = {{http://dx.doi.org/10.1111/eci.12643}}, doi = {{10.1111/eci.12643}}, volume = {{46}}, year = {{2016}}, }