Insulin release and pancreatic insulin is reduced in young prediabetic BB rats
(1986) In Acta Endocrinologica 112(3). p.367-371- Abstract
The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P <... (More)
The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.
(Less)
- author
- Svenningsen, A.
; Dyrberg, T.
; Markholst, H.
; Binder, C.
and Lernmark, A.
LU
- publishing date
- 1986-09-24
- type
- Contribution to journal
- publication status
- published
- in
- Acta Endocrinologica
- volume
- 112
- issue
- 3
- pages
- 5 pages
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- scopus:0022541591
- pmid:3529783
- ISSN
- 0001-5598
- language
- English
- LU publication?
- no
- id
- dca00e97-b8b3-473e-9731-ca6689277b5a
- date added to LUP
- 2019-09-16 12:35:21
- date last changed
- 2024-03-13 08:29:08
@article{dca00e97-b8b3-473e-9731-ca6689277b5a, abstract = {{<p>The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.</p>}}, author = {{Svenningsen, A. and Dyrberg, T. and Markholst, H. and Binder, C. and Lernmark, A.}}, issn = {{0001-5598}}, language = {{eng}}, month = {{09}}, number = {{3}}, pages = {{367--371}}, publisher = {{Society of the European Journal of Endocrinology}}, series = {{Acta Endocrinologica}}, title = {{Insulin release and pancreatic insulin is reduced in young prediabetic BB rats}}, volume = {{112}}, year = {{1986}}, }