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Insulin release and pancreatic insulin is reduced in young prediabetic BB rats

Svenningsen, A. ; Dyrberg, T. ; Markholst, H. ; Binder, C. and Lernmark, A. LU orcid (1986) In Acta Endocrinologica 112(3). p.367-371
Abstract

The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P <... (More)

The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P < 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Acta Endocrinologica
volume
112
issue
3
pages
5 pages
publisher
Society of the European Journal of Endocrinology
external identifiers
  • scopus:0022541591
  • pmid:3529783
ISSN
0001-5598
language
English
LU publication?
no
id
dca00e97-b8b3-473e-9731-ca6689277b5a
date added to LUP
2019-09-16 12:35:21
date last changed
2024-03-13 08:29:08
@article{dca00e97-b8b3-473e-9731-ca6689277b5a,
  abstract     = {{<p>The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82-84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P &lt; 0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P &lt; 0.01). The extractable pancreatic insulin was 30% (P &lt; 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20-40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.</p>}},
  author       = {{Svenningsen, A. and Dyrberg, T. and Markholst, H. and Binder, C. and Lernmark, A.}},
  issn         = {{0001-5598}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{3}},
  pages        = {{367--371}},
  publisher    = {{Society of the European Journal of Endocrinology}},
  series       = {{Acta Endocrinologica}},
  title        = {{Insulin release and pancreatic insulin is reduced in young prediabetic BB rats}},
  volume       = {{112}},
  year         = {{1986}},
}