A treatment planning comparison of contemporary photon-based radiation techniques for breast cancer
(2018) In Physics and imaging in radiation oncology 7. p.32-38- Abstract
Background and purpose: Adjuvant radiation therapy (RT) of the whole breast (WB) is still the standard treatment for early breast cancer. A variety of radiation techniques is currently available according to different delivery strategies. This study aims to provide a comparison of six treatment planning strategies commonly adopted for breast-conserving adjuvant RT and to use the Pareto concept in an attempt to assess the degree of plan optimization. Materials and methods: Two groups of six left- and five right-sided cases with different dose prescriptions were involved (22 patients in total). Field-in-Field (FiF), two and four Fields static-IMRT (sIMRT-2f and sIMRT-4f), Volumetric-Modulated-Arc-Therapy (VMAT), Helical Tomotherapy (HT)... (More)
Background and purpose: Adjuvant radiation therapy (RT) of the whole breast (WB) is still the standard treatment for early breast cancer. A variety of radiation techniques is currently available according to different delivery strategies. This study aims to provide a comparison of six treatment planning strategies commonly adopted for breast-conserving adjuvant RT and to use the Pareto concept in an attempt to assess the degree of plan optimization. Materials and methods: Two groups of six left- and five right-sided cases with different dose prescriptions were involved (22 patients in total). Field-in-Field (FiF), two and four Fields static-IMRT (sIMRT-2f and sIMRT-4f), Volumetric-Modulated-Arc-Therapy (VMAT), Helical Tomotherapy (HT) and Static-Angles Tomotherapy (TomoDirect™ – TD) were planned. Dose volume constraints were taken from the RTOG protocol 1005. Pareto fronts were built for a selected case to evaluate the reliability of the plan optimization process. Results: The best target dose coverage was observed for TD able to improve significantly (p < 0.01) the V95% in a range varying from 1.2% to 7.5% compared to other techniques. The V105% was significantly reduced up to 2% for HT (p < 0.05) although FiF and VMAT produced similar values. For the ipsilateral lung, V5Gy, V10Gy and Dmean were significantly lower than all other techniques (p < 0.02) for TD while the lowest value of V20Gy was observed for HT. The maximum dose to contralateral breast was significantly lowest for TD (p < 0.02) and for FiF (p < 0.05). Minor differences were observed for the heart in left-sided patients. Plans for all tested techniques were found to lie on their respective Pareto fronts. Conclusions: Overall, TD provided significantly better results in terms of target coverage and dose sparing of ipsilateral lung with respect to all other evaluated techniques. It also significantly minimized dose to contralateral breast together with FiF. Pareto front analysis confirmed the reliability of the optimization for a selected case.
(Less)
- author
- Zeverino, Michele ; Petersson, Kristoffer LU ; Kyroudi, Archonteia ; Jeanneret-Sozzi, Wendy ; Bourhis, Jean ; Bochud, Francois and Moeckli, Raphael
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- keywords
- Pareto front, Planning comparison, Treatment planning, Whole-breast irradiation
- in
- Physics and imaging in radiation oncology
- volume
- 7
- pages
- 32 - 38
- publisher
- Elsevier
- external identifiers
-
- scopus:85070485699
- ISSN
- 2405-6316
- DOI
- 10.1016/j.phro.2018.08.002
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2018 The Authors
- id
- dd451f00-19d3-4de9-8856-2bea333765f7
- date added to LUP
- 2021-11-03 18:16:53
- date last changed
- 2022-04-03 21:29:25
@article{dd451f00-19d3-4de9-8856-2bea333765f7,
abstract = {{<p>Background and purpose: Adjuvant radiation therapy (RT) of the whole breast (WB) is still the standard treatment for early breast cancer. A variety of radiation techniques is currently available according to different delivery strategies. This study aims to provide a comparison of six treatment planning strategies commonly adopted for breast-conserving adjuvant RT and to use the Pareto concept in an attempt to assess the degree of plan optimization. Materials and methods: Two groups of six left- and five right-sided cases with different dose prescriptions were involved (22 patients in total). Field-in-Field (FiF), two and four Fields static-IMRT (sIMRT-2f and sIMRT-4f), Volumetric-Modulated-Arc-Therapy (VMAT), Helical Tomotherapy (HT) and Static-Angles Tomotherapy (TomoDirect™ – TD) were planned. Dose volume constraints were taken from the RTOG protocol 1005. Pareto fronts were built for a selected case to evaluate the reliability of the plan optimization process. Results: The best target dose coverage was observed for TD able to improve significantly (p < 0.01) the V95% in a range varying from 1.2% to 7.5% compared to other techniques. The V105% was significantly reduced up to 2% for HT (p < 0.05) although FiF and VMAT produced similar values. For the ipsilateral lung, V5Gy, V10Gy and Dmean were significantly lower than all other techniques (p < 0.02) for TD while the lowest value of V20Gy was observed for HT. The maximum dose to contralateral breast was significantly lowest for TD (p < 0.02) and for FiF (p < 0.05). Minor differences were observed for the heart in left-sided patients. Plans for all tested techniques were found to lie on their respective Pareto fronts. Conclusions: Overall, TD provided significantly better results in terms of target coverage and dose sparing of ipsilateral lung with respect to all other evaluated techniques. It also significantly minimized dose to contralateral breast together with FiF. Pareto front analysis confirmed the reliability of the optimization for a selected case.</p>}},
author = {{Zeverino, Michele and Petersson, Kristoffer and Kyroudi, Archonteia and Jeanneret-Sozzi, Wendy and Bourhis, Jean and Bochud, Francois and Moeckli, Raphael}},
issn = {{2405-6316}},
keywords = {{Pareto front; Planning comparison; Treatment planning; Whole-breast irradiation}},
language = {{eng}},
pages = {{32--38}},
publisher = {{Elsevier}},
series = {{Physics and imaging in radiation oncology}},
title = {{A treatment planning comparison of contemporary photon-based radiation techniques for breast cancer}},
url = {{http://dx.doi.org/10.1016/j.phro.2018.08.002}},
doi = {{10.1016/j.phro.2018.08.002}},
volume = {{7}},
year = {{2018}},
}