A paradigm shift design of functional monomers for developing molecularly imprinted polymers
Li, Qianjin LU ; Ling, Baoping ; Jiang, Lingdong LU and Ye, Lei LU
(2018)
In Chemical Engineering Journal
350.
p.217-224
- Abstract
Functional monomers play a key role in preparing molecularly imprinted polymers (MIPs) by forming complex with templates to create recognition sites in the polymers. In this paper, a new strategy was proposed to design functional monomers for efficient MIPs synthesis. This strategy dated from the investigations on previously developed MIPs. In propranolol imprinting process, methacrylic acid has always been used as a functional monomer, due to the efficient hydrogen bonding interactions between the carboxyl group in methacrylic acid and the 2-hydroxylethylamine group in propranolol. Given this, we assumed that a functional monomer having a 2-hydroxylethylamine moiety may be used to imprint carboxylic acid molecules e.g. naproxen. To... (More)
Functional monomers play a key role in preparing molecularly imprinted polymers (MIPs) by forming complex with templates to create recognition sites in the polymers. In this paper, a new strategy was proposed to design functional monomers for efficient MIPs synthesis. This strategy dated from the investigations on previously developed MIPs. In propranolol imprinting process, methacrylic acid has always been used as a functional monomer, due to the efficient hydrogen bonding interactions between the carboxyl group in methacrylic acid and the 2-hydroxylethylamine group in propranolol. Given this, we assumed that a functional monomer having a 2-hydroxylethylamine moiety may be used to imprint carboxylic acid molecules e.g. naproxen. To demonstrate this idea, a new monomer 2-hydroxy-3-(isopropylamino)propyl methacrylate (HIMA) was designed. Computation results, by means of density functional theory method, revealed that HIMA could form a stable complex with naproxen through hydrogen bonding interactions with the carboxylic acid group. HIMA was then used to synthesize naproxen-imprinted polymers via precipitation polymerization. Binding experiments showed that all the MIPs could selectively recognize naproxen, confirming the feasibility of our paradigm shift in functional monomer design. The new functional monomer HIMA is a promising ligand that may be used to imprint other molecules having carboxylic acid or phosphoric acid groups. The paradigm shift in this study thereby opens a new avenue to design functional monomers for developing MIPs.
(Less)
- author
- Li, Qianjin
LU
; Ling, Baoping
; Jiang, Lingdong
LU
and Ye, Lei
LU
- organization
- publishing date
- 2018-10-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Carboxylic acid, Functional monomer, Molecularly imprinted polymer, Naproxen, Propranolol
- in
- Chemical Engineering Journal
- volume
- 350
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85047815830
- ISSN
- 1385-8947
- DOI
- 10.1016/j.cej.2018.05.187
- language
- English
- LU publication?
- yes
- id
- ddbe8f20-053c-4398-978c-da6650796758
- date added to LUP
- 2018-06-11 10:11:19
- date last changed
- 2022-03-02 06:35:17
@article{ddbe8f20-053c-4398-978c-da6650796758,
abstract = {{<p>Functional monomers play a key role in preparing molecularly imprinted polymers (MIPs) by forming complex with templates to create recognition sites in the polymers. In this paper, a new strategy was proposed to design functional monomers for efficient MIPs synthesis. This strategy dated from the investigations on previously developed MIPs. In propranolol imprinting process, methacrylic acid has always been used as a functional monomer, due to the efficient hydrogen bonding interactions between the carboxyl group in methacrylic acid and the 2-hydroxylethylamine group in propranolol. Given this, we assumed that a functional monomer having a 2-hydroxylethylamine moiety may be used to imprint carboxylic acid molecules e.g. naproxen. To demonstrate this idea, a new monomer 2-hydroxy-3-(isopropylamino)propyl methacrylate (HIMA) was designed. Computation results, by means of density functional theory method, revealed that HIMA could form a stable complex with naproxen through hydrogen bonding interactions with the carboxylic acid group. HIMA was then used to synthesize naproxen-imprinted polymers via precipitation polymerization. Binding experiments showed that all the MIPs could selectively recognize naproxen, confirming the feasibility of our paradigm shift in functional monomer design. The new functional monomer HIMA is a promising ligand that may be used to imprint other molecules having carboxylic acid or phosphoric acid groups. The paradigm shift in this study thereby opens a new avenue to design functional monomers for developing MIPs.</p>}},
author = {{Li, Qianjin and Ling, Baoping and Jiang, Lingdong and Ye, Lei}},
issn = {{1385-8947}},
keywords = {{Carboxylic acid; Functional monomer; Molecularly imprinted polymer; Naproxen; Propranolol}},
language = {{eng}},
month = {{10}},
pages = {{217--224}},
publisher = {{Elsevier}},
series = {{Chemical Engineering Journal}},
title = {{A paradigm shift design of functional monomers for developing molecularly imprinted polymers}},
url = {{http://dx.doi.org/10.1016/j.cej.2018.05.187}},
doi = {{10.1016/j.cej.2018.05.187}},
volume = {{350}},
year = {{2018}},
}