Arterial spin-labeling in children with brain tumor : A meta-analysis
(2018) In American Journal of Neuroradiology 39(8). p.1543-1549- Abstract
BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data... (More)
BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43- 48.82 mL/min/100 g), I2 74, P .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P .001, I2 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method. LIMITATIONS: Included tumor types, analysis method, and original data varied among included studies. CONCLUSIONS: Arterial spin-labeling- derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.
(Less)
- author
- Delgado, A. F. ; De Luca, F. ; Hanagandi, P. and Van Westen, D. LU
- organization
- publishing date
- 2018-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Neuroradiology
- volume
- 39
- issue
- 8
- pages
- 7 pages
- publisher
- American Society of Neuroradiology
- external identifiers
-
- pmid:30072368
- scopus:85051441753
- ISSN
- 0195-6108
- DOI
- 10.3174/ajnr.A5727
- language
- English
- LU publication?
- yes
- id
- ddeb619e-83db-4791-80b5-3e26c7b56327
- date added to LUP
- 2018-09-11 08:34:41
- date last changed
- 2024-07-22 21:41:01
@article{ddeb619e-83db-4791-80b5-3e26c7b56327, abstract = {{<p>BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43- 48.82 mL/min/100 g), I<sup>2</sup> 74, P .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P .001, I<sup>2</sup> 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method. LIMITATIONS: Included tumor types, analysis method, and original data varied among included studies. CONCLUSIONS: Arterial spin-labeling- derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.</p>}}, author = {{Delgado, A. F. and De Luca, F. and Hanagandi, P. and Van Westen, D.}}, issn = {{0195-6108}}, language = {{eng}}, month = {{08}}, number = {{8}}, pages = {{1543--1549}}, publisher = {{American Society of Neuroradiology}}, series = {{American Journal of Neuroradiology}}, title = {{Arterial spin-labeling in children with brain tumor : A meta-analysis}}, url = {{http://dx.doi.org/10.3174/ajnr.A5727}}, doi = {{10.3174/ajnr.A5727}}, volume = {{39}}, year = {{2018}}, }