Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
(2020) In Cell Metabolism 32(4). p.643-653- Abstract
Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e1326184-217b-4f3c-bb6a-9b779a2f7dc4
- author
- Koh, Ara ; Mannerås-Holm, Louise ; Yunn, Na Oh ; Nilsson, Peter M. LU ; Ryu, Sung Ho ; Molinaro, Antonio ; Perkins, Rosie ; Smith, J. Gustav and Bäckhed, Fredrik
- organization
- publishing date
- 2020-10-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AMPK, diabetes, imidazole propionate, individual variations, metformin, microbial metabolites, microbiota, p38γ
- in
- Cell Metabolism
- volume
- 32
- issue
- 4
- pages
- 11 pages
- publisher
- Cell Press
- external identifiers
-
- pmid:32783890
- scopus:85090062838
- ISSN
- 1550-4131
- DOI
- 10.1016/j.cmet.2020.07.012
- language
- English
- LU publication?
- yes
- id
- e1326184-217b-4f3c-bb6a-9b779a2f7dc4
- date added to LUP
- 2020-09-25 12:07:14
- date last changed
- 2024-09-19 05:57:07
@article{e1326184-217b-4f3c-bb6a-9b779a2f7dc4, abstract = {{<p>Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.</p>}}, author = {{Koh, Ara and Mannerås-Holm, Louise and Yunn, Na Oh and Nilsson, Peter M. and Ryu, Sung Ho and Molinaro, Antonio and Perkins, Rosie and Smith, J. Gustav and Bäckhed, Fredrik}}, issn = {{1550-4131}}, keywords = {{AMPK; diabetes; imidazole propionate; individual variations; metformin; microbial metabolites; microbiota; p38γ}}, language = {{eng}}, month = {{10}}, number = {{4}}, pages = {{643--653}}, publisher = {{Cell Press}}, series = {{Cell Metabolism}}, title = {{Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation}}, url = {{http://dx.doi.org/10.1016/j.cmet.2020.07.012}}, doi = {{10.1016/j.cmet.2020.07.012}}, volume = {{32}}, year = {{2020}}, }