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Studies of different secondary metabolites : Natural products from the mevalonate pathway

Gonzales Ramirez, Mariela Alejandra LU (2021)
Abstract
Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus... (More)
Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.
From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.
Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents. (Less)
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author
supervisor
opponent
  • Doctor Peña Rodríguez, Luis Manuel, Centro de Investigación Científica de Yucatán, Mérida, Yucatán, México
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Natural products, fungi, Galiellalactone, Galiella rufa, Trichilia adolfi, benzofuran
pages
157 pages
publisher
Lund University
defense location
Kemicentrum Sal C Join via zoom: https://lu-se.zoom.us/j/69776660302?pwd=Zzg2bnVqbTliUkFpZ1dsdFp6WlJGdz09
defense date
2021-08-26 14:00:00
ISBN
978-91-7895-935-8
978-91-7895-936-5
language
English
LU publication?
yes
id
e1b5e4a0-ade3-43e5-b5f6-70c615af17e9
date added to LUP
2021-06-07 09:17:00
date last changed
2021-06-10 11:06:34
@phdthesis{e1b5e4a0-ade3-43e5-b5f6-70c615af17e9,
  abstract     = {{Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.<br/>Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.<br/>In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.<br/>From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.<br/>From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.<br/>Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents.}},
  author       = {{Gonzales Ramirez, Mariela Alejandra}},
  isbn         = {{978-91-7895-935-8}},
  keywords     = {{Natural products; fungi; Galiellalactone; Galiella rufa; Trichilia adolfi; benzofuran}},
  language     = {{eng}},
  month        = {{06}},
  publisher    = {{Lund University}},
  school       = {{Lund University}},
  title        = {{Studies of different secondary metabolites : Natural products from the mevalonate pathway}},
  url          = {{https://lup.lub.lu.se/search/files/99001735/Mariela_G_Thesis_E_version.pdf}},
  year         = {{2021}},
}