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Scandinavian Multicenter Acute Subdural Hematoma (SMASH): Study Protocol for a Multinational Population-Based Consecutive Cohort

Bartek, Jiri ; Laugesen, Christian ; Mirza, Sadia ; Forsse, Axel ; Petersen, Michael Anders ; Corell, Alba ; Dyhrfort, Philip Wilhelm ; Nittby, Henrietta LU ; Reen, Linus LU and Zolfaghari, Shaian LU orcid , et al. (2019) In Neurosurgery 84(3). p.799-803
Abstract

BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.

OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.

METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr)... (More)

BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.

OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.

METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.

EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.

DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Neurosurgery
volume
84
issue
3
pages
799 - 803
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:29762769
  • scopus:85061593542
ISSN
0148-396X
DOI
10.1093/neuros/nyy173
language
English
LU publication?
no
id
e2217b3d-5dd8-4904-b61b-6c07a84e9fe2
date added to LUP
2019-02-14 10:33:11
date last changed
2025-04-04 15:04:18
@article{e2217b3d-5dd8-4904-b61b-6c07a84e9fe2,
  abstract     = {{<p>BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.</p><p>OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.</p><p>METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.</p><p>EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.</p><p>DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.</p>}},
  author       = {{Bartek, Jiri and Laugesen, Christian and Mirza, Sadia and Forsse, Axel and Petersen, Michael Anders and Corell, Alba and Dyhrfort, Philip Wilhelm and Nittby, Henrietta and Reen, Linus and Zolfaghari, Shaian and Tobieson, Lovisa and Carlsvärd, Björn and Bergholt, Bo and Bashir, Asma and Soerensen, Preben and Bilgin, Arzu and Johansson, Conny and Lindvall, Peter and Förander, Petter and Bellander, Bo-Michael and Springborg, Jacob B and Jakola, Asgeir S}},
  issn         = {{0148-396X}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{799--803}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Neurosurgery}},
  title        = {{Scandinavian Multicenter Acute Subdural Hematoma (SMASH): Study Protocol for a Multinational Population-Based Consecutive Cohort}},
  url          = {{http://dx.doi.org/10.1093/neuros/nyy173}},
  doi          = {{10.1093/neuros/nyy173}},
  volume       = {{84}},
  year         = {{2019}},
}