B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches
(2020) In Cell Reports 30(6). p.5-1922- Abstract
SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.
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https://lup.lub.lu.se/record/e2c9799b-fcb4-425b-be75-bc17ba8a7303
- author
- Biram, Adi ; Winter, Eitan ; Denton, Alice E. ; Zaretsky, Irina ; Dassa, Bareket ; Bemark, Mats LU ; Linterman, Michelle A. ; Yaari, Gur and Shulman, Ziv
- publishing date
- 2020-02-11
- type
- Contribution to journal
- publication status
- published
- keywords
- antibody, B cells, clonal diversification, germinal center, IgA, Peyer's patches, plasma cells, SAP, T follicular helper cells
- in
- Cell Reports
- volume
- 30
- issue
- 6
- pages
- 5 - 1922
- publisher
- Cell Press
- external identifiers
-
- scopus:85079170606
- pmid:32049020
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2020.01.032
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2020 The Authors
- id
- e2c9799b-fcb4-425b-be75-bc17ba8a7303
- date added to LUP
- 2023-11-28 10:10:42
- date last changed
- 2024-06-20 18:05:00
@article{e2c9799b-fcb4-425b-be75-bc17ba8a7303, abstract = {{<p>SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.</p>}}, author = {{Biram, Adi and Winter, Eitan and Denton, Alice E. and Zaretsky, Irina and Dassa, Bareket and Bemark, Mats and Linterman, Michelle A. and Yaari, Gur and Shulman, Ziv}}, issn = {{2211-1247}}, keywords = {{antibody; B cells; clonal diversification; germinal center; IgA; Peyer's patches; plasma cells; SAP; T follicular helper cells}}, language = {{eng}}, month = {{02}}, number = {{6}}, pages = {{5--1922}}, publisher = {{Cell Press}}, series = {{Cell Reports}}, title = {{B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches}}, url = {{http://dx.doi.org/10.1016/j.celrep.2020.01.032}}, doi = {{10.1016/j.celrep.2020.01.032}}, volume = {{30}}, year = {{2020}}, }