Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces
Tesei, Giulio LU ; Hellstrand, Erik LU ; Sanagavarapu, Kalyani LU ; Linse, Sara LU ; Sparr, Emma LU ; Vácha, Robert and Lund, Mikael LU
(2018)
In Langmuir
34(4).
p.1266-1273
- Abstract
Amyloid aggregates are associated with a range of human neurodegenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to... (More)
Amyloid aggregates are associated with a range of human neurodegenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.
(Less)
- author
- Tesei, Giulio
LU
; Hellstrand, Erik
LU
; Sanagavarapu, Kalyani
LU
; Linse, Sara
LU
; Sparr, Emma
LU
; Vácha, Robert
and Lund, Mikael
LU
- organization
- publishing date
- 2018-01-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 34
- issue
- 4
- pages
- 8 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:29284092
- scopus:85041447320
- ISSN
- 0743-7463
- DOI
- 10.1021/acs.langmuir.7b03155
- language
- English
- LU publication?
- yes
- id
- e41ce99f-7f0f-44cd-913a-0c8eebd58d69
- date added to LUP
- 2018-02-21 12:41:53
- date last changed
- 2024-06-24 10:11:21
@article{e41ce99f-7f0f-44cd-913a-0c8eebd58d69,
abstract = {{<p>Amyloid aggregates are associated with a range of human neurodegenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.</p>}},
author = {{Tesei, Giulio and Hellstrand, Erik and Sanagavarapu, Kalyani and Linse, Sara and Sparr, Emma and Vácha, Robert and Lund, Mikael}},
issn = {{0743-7463}},
language = {{eng}},
month = {{01}},
number = {{4}},
pages = {{1266--1273}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Langmuir}},
title = {{Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces}},
url = {{http://dx.doi.org/10.1021/acs.langmuir.7b03155}},
doi = {{10.1021/acs.langmuir.7b03155}},
volume = {{34}},
year = {{2018}},
}