Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
(2019) In Nature Genetics 51. p.452-469- Abstract
- Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e480e762-4ec0-490f-8de5-8201f81cca66
- author
- Justice, Anne E ; Franks, Paul LU ; North, Kari E and Lindgren, Cecilia M
- author collaboration
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 51
- pages
- 452 - 469
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85061697378
- pmid:30778226
- ISSN
- 1546-1718
- DOI
- 10.1038/s41588-018-0334-2
- language
- English
- LU publication?
- yes
- id
- e480e762-4ec0-490f-8de5-8201f81cca66
- date added to LUP
- 2019-03-05 12:10:49
- date last changed
- 2022-04-25 21:26:33
@article{e480e762-4ec0-490f-8de5-8201f81cca66, abstract = {{Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF}}, author = {{Justice, Anne E and Franks, Paul and North, Kari E and Lindgren, Cecilia M}}, issn = {{1546-1718}}, language = {{eng}}, pages = {{452--469}}, publisher = {{Nature Publishing Group}}, series = {{Nature Genetics}}, title = {{Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution}}, url = {{http://dx.doi.org/10.1038/s41588-018-0334-2}}, doi = {{10.1038/s41588-018-0334-2}}, volume = {{51}}, year = {{2019}}, }