Mitochondria and the Brain : Bioenergetics and Beyond
Belenguer, Pascale ; Duarte, João M.N. LU
; Schuck, Patrícia F.
and Ferreira, Gustavo C.
(2019)
In Neurotoxicity Research
36(2).
p.219-238
- Abstract
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of... (More)
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.
(Less)
- author
- Belenguer, Pascale
; Duarte, João M.N.
LU
; Schuck, Patrícia F.
and Ferreira, Gustavo C.
- organization
- publishing date
- 2019-06-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain metabolism, Mitochondria, MRS, Neurogenesis
- in
- Neurotoxicity Research
- volume
- 36
- issue
- 2
- pages
- 219 - 238
- publisher
- Springer
- external identifiers
-
- pmid:31152314
- scopus:85066479216
- ISSN
- 1029-8428
- DOI
- 10.1007/s12640-019-00061-7
- language
- English
- LU publication?
- yes
- id
- e4d80061-c1cf-4d9c-ae6f-9f13ade39a9d
- date added to LUP
- 2019-06-25 12:11:56
- date last changed
- 2024-07-09 19:27:56
@article{e4d80061-c1cf-4d9c-ae6f-9f13ade39a9d,
abstract = {{<p>The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.</p>}},
author = {{Belenguer, Pascale and Duarte, João M.N. and Schuck, Patrícia F. and Ferreira, Gustavo C.}},
issn = {{1029-8428}},
keywords = {{Brain metabolism; Mitochondria; MRS; Neurogenesis}},
language = {{eng}},
month = {{06}},
number = {{2}},
pages = {{219--238}},
publisher = {{Springer}},
series = {{Neurotoxicity Research}},
title = {{Mitochondria and the Brain : Bioenergetics and Beyond}},
url = {{http://dx.doi.org/10.1007/s12640-019-00061-7}},
doi = {{10.1007/s12640-019-00061-7}},
volume = {{36}},
year = {{2019}},
}