Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7
(2020) In Structure 28(2). p.3-222- Abstract
AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e6a6d9e1-70ef-4dd3-b22e-05090fe0e451
- author
- de Maré, Sofia W. LU ; Venskutonytė, Raminta LU ; Eltschkner, Sandra LU ; de Groot, Bert L. and Lindkvist-Petersson, Karin LU
- organization
- publishing date
- 2020-02-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adipocyte, AQP7, aquaglyceroporin, aquaporin 7, atomistic MD simulations, glycerol channel, water, X-ray structure
- in
- Structure
- volume
- 28
- issue
- 2
- pages
- 3 - 222
- publisher
- Cell Press
- external identifiers
-
- pmid:31831212
- scopus:85078470700
- ISSN
- 0969-2126
- DOI
- 10.1016/j.str.2019.11.011
- language
- English
- LU publication?
- yes
- id
- e6a6d9e1-70ef-4dd3-b22e-05090fe0e451
- date added to LUP
- 2020-02-04 15:10:32
- date last changed
- 2024-09-18 17:26:45
@article{e6a6d9e1-70ef-4dd3-b22e-05090fe0e451, abstract = {{<p>AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.</p>}}, author = {{de Maré, Sofia W. and Venskutonytė, Raminta and Eltschkner, Sandra and de Groot, Bert L. and Lindkvist-Petersson, Karin}}, issn = {{0969-2126}}, keywords = {{adipocyte; AQP7; aquaglyceroporin; aquaporin 7; atomistic MD simulations; glycerol channel; water; X-ray structure}}, language = {{eng}}, month = {{02}}, number = {{2}}, pages = {{3--222}}, publisher = {{Cell Press}}, series = {{Structure}}, title = {{Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7}}, url = {{http://dx.doi.org/10.1016/j.str.2019.11.011}}, doi = {{10.1016/j.str.2019.11.011}}, volume = {{28}}, year = {{2020}}, }