Tumor growth rate estimations in a breast cancer screening population
(2022) 16th International Workshop on Breast Imaging, IWBI 2022 In Proceedings of SPIE - The International Society for Optical Engineering 12286.- Abstract
Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The... (More)
Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The analyzed cases were selected among women with visible tumors in two consecutive screening exams. The tumor size was measured in two orthogonal directions. The average of the two measurements was used in the analysis. The mean time and the corresponding standard deviation (SD) between the two consecutive mammograms were 744 ± 73 days. The mean TVDT and SD were 637 ± 428 days (range 159-2373 days). Future work will include the analysis of a larger number of women and a stratification of TVDT related to screening intervals.
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- author
- Tomic, Hanna LU ; Ohashi, Akane LU ; Dahlblom, Victor LU ; Bjerkén, Anna LU ; Förnvik, Daniel LU ; Dustler, Magnus LU ; Zackrisson, Sophia LU ; Tingberg, Anders LU and Bakic, Predrag LU
- organization
- publishing date
- 2022
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- breast cancer, Tumor growth, tumor volume doubling time
- host publication
- 16th International Workshop on Breast Imaging, IWBI 2022
- series title
- Proceedings of SPIE - The International Society for Optical Engineering
- editor
- Bosmans, Hilde ; Marshall, Nicholas and Van Ongeval, Chantal
- volume
- 12286
- article number
- 1228613
- publisher
- SPIE
- conference name
- 16th International Workshop on Breast Imaging, IWBI 2022
- conference location
- Leuven, Belgium
- conference dates
- 2022-05-22 - 2022-05-25
- external identifiers
-
- scopus:85136113683
- ISSN
- 1996-756X
- 0277-786X
- ISBN
- 9781510655843
- DOI
- 10.1117/12.2625730
- language
- English
- LU publication?
- yes
- id
- e9c618e7-ccf4-4f78-86ae-d1593ea34cc1
- date added to LUP
- 2022-10-07 13:31:15
- date last changed
- 2024-08-09 00:53:15
@inproceedings{e9c618e7-ccf4-4f78-86ae-d1593ea34cc1, abstract = {{<p>Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Screening Trial (MBTST). The trial included 14 848 women in whom 139 cancers were detected. Out of those, 101 spiculated or circumscribed masses, had prior images available, making them suitable for tumor growth evaluation. In the preliminary analysis of images from 30 women, tumor size was measured in mammograms from MBTST and prior images. The analyzed cases were selected among women with visible tumors in two consecutive screening exams. The tumor size was measured in two orthogonal directions. The average of the two measurements was used in the analysis. The mean time and the corresponding standard deviation (SD) between the two consecutive mammograms were 744 ± 73 days. The mean TVDT and SD were 637 ± 428 days (range 159-2373 days). Future work will include the analysis of a larger number of women and a stratification of TVDT related to screening intervals. </p>}}, author = {{Tomic, Hanna and Ohashi, Akane and Dahlblom, Victor and Bjerkén, Anna and Förnvik, Daniel and Dustler, Magnus and Zackrisson, Sophia and Tingberg, Anders and Bakic, Predrag}}, booktitle = {{16th International Workshop on Breast Imaging, IWBI 2022}}, editor = {{Bosmans, Hilde and Marshall, Nicholas and Van Ongeval, Chantal}}, isbn = {{9781510655843}}, issn = {{1996-756X}}, keywords = {{breast cancer; Tumor growth; tumor volume doubling time}}, language = {{eng}}, publisher = {{SPIE}}, series = {{Proceedings of SPIE - The International Society for Optical Engineering}}, title = {{Tumor growth rate estimations in a breast cancer screening population}}, url = {{http://dx.doi.org/10.1117/12.2625730}}, doi = {{10.1117/12.2625730}}, volume = {{12286}}, year = {{2022}}, }