Tuning Pluronic F127 phase transitions by adding physiological amounts of salts : A rheology, SAXS, and NMR investigation
(2024) In European Polymer Journal 204.- Abstract
Specific ion (Hofmeister) effects in colloid and biological systems represented a scientific challenge for more than 100 years. Recently, possible applications, based on their rationalization, are emerging. Here, Cl-, SO42-, SCN- anions and Na+, K+, Mg2+ cations are added at physiological concentration (∼0.15 mol/kg) to Pluronic F127 20 wt% aqueous solutions to suitably tune phase transitions for a smart drug delivery platform. Rheological measurements, along with SAXS and NMR self-diffusion experiments, are used to carefully characterize the prepared F127/salt-based formulations. The critical micellar temperature (cmt), the hard-gel formation temperature... (More)
Specific ion (Hofmeister) effects in colloid and biological systems represented a scientific challenge for more than 100 years. Recently, possible applications, based on their rationalization, are emerging. Here, Cl-, SO42-, SCN- anions and Na+, K+, Mg2+ cations are added at physiological concentration (∼0.15 mol/kg) to Pluronic F127 20 wt% aqueous solutions to suitably tune phase transitions for a smart drug delivery platform. Rheological measurements, along with SAXS and NMR self-diffusion experiments, are used to carefully characterize the prepared F127/salt-based formulations. The critical micellar temperature (cmt), the hard-gel formation temperature (Thg), liquid crystal structures, and self-diffusion coefficients are determined. The cmt and Thg values of F127/salt formulations are lower than that of F127 20 wt% sample, following an anionic Hofmeister series: SO42- < Cl- < SCN-. All added salts significantly increase storage modulus and complex viscosity with maximum values occurring at T around 40 °C. SAXS data confirm that added salts preserve cubic liquid crystal phases. NMR self-diffusion analysis highlights that the intermolecular interactions and mobility of F127 unimers/aggregates are ion specific at 16 °C but not at 40 °C. These findings suggest that F127/salt-based formulations may constitute a versatile thermosensitive platform for drug delivery able to assure sustained release in topical or surgery administrations, in the range of temperatures 30–45 °C.
(Less)
- author
- Russo, Giovanni ; Rossella Delpiano, G. ; Carucci, Cristina LU ; Grosso, Massimiliano ; Dessì, Claudia ; Söderman, Olle LU ; Lindman, Björn LU ; Monduzzi, Maura and Salis, Andrea LU
- organization
- publishing date
- 2024-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hofmeister series, Pluronic F127, Thermoresponsive hydrogels, Tunable phase transitions
- in
- European Polymer Journal
- volume
- 204
- article number
- 112714
- publisher
- Elsevier
- external identifiers
-
- scopus:85181115966
- ISSN
- 0014-3057
- DOI
- 10.1016/j.eurpolymj.2023.112714
- language
- English
- LU publication?
- yes
- id
- ea9d0962-5d99-4d81-8a3a-ab5cd68309c2
- date added to LUP
- 2024-02-09 14:56:34
- date last changed
- 2024-02-09 14:58:35
@article{ea9d0962-5d99-4d81-8a3a-ab5cd68309c2, abstract = {{<p>Specific ion (Hofmeister) effects in colloid and biological systems represented a scientific challenge for more than 100 years. Recently, possible applications, based on their rationalization, are emerging. Here, Cl<sup>-</sup>, SO<sub>4</sub><sup>2-</sup>, SCN<sup>-</sup> anions and Na<sup>+</sup>, K<sup>+</sup>, Mg<sup>2+</sup> cations are added at physiological concentration (∼0.15 mol/kg) to Pluronic F127 20 wt% aqueous solutions to suitably tune phase transitions for a smart drug delivery platform. Rheological measurements, along with SAXS and NMR self-diffusion experiments, are used to carefully characterize the prepared F127/salt-based formulations. The critical micellar temperature (cmt), the hard-gel formation temperature (T<sub>hg</sub>), liquid crystal structures, and self-diffusion coefficients are determined. The cmt and T<sub>hg</sub> values of F127/salt formulations are lower than that of F127 20 wt% sample, following an anionic Hofmeister series: SO<sub>4</sub><sup>2-</sup> < Cl<sup>-</sup> < SCN<sup>-</sup>. All added salts significantly increase storage modulus and complex viscosity with maximum values occurring at T around 40 °C. SAXS data confirm that added salts preserve cubic liquid crystal phases. NMR self-diffusion analysis highlights that the intermolecular interactions and mobility of F127 unimers/aggregates are ion specific at 16 °C but not at 40 °C. These findings suggest that F127/salt-based formulations may constitute a versatile thermosensitive platform for drug delivery able to assure sustained release in topical or surgery administrations, in the range of temperatures 30–45 °C.</p>}}, author = {{Russo, Giovanni and Rossella Delpiano, G. and Carucci, Cristina and Grosso, Massimiliano and Dessì, Claudia and Söderman, Olle and Lindman, Björn and Monduzzi, Maura and Salis, Andrea}}, issn = {{0014-3057}}, keywords = {{Hofmeister series; Pluronic F127; Thermoresponsive hydrogels; Tunable phase transitions}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{European Polymer Journal}}, title = {{Tuning Pluronic F127 phase transitions by adding physiological amounts of salts : A rheology, SAXS, and NMR investigation}}, url = {{http://dx.doi.org/10.1016/j.eurpolymj.2023.112714}}, doi = {{10.1016/j.eurpolymj.2023.112714}}, volume = {{204}}, year = {{2024}}, }