[The effect of aldosterone on the second messenger systems in the rat kidney]
(1991) In Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova 77(10). p.9-114- Abstract
The effect of aldosterone on the cAMP level, the state of inositol-phosphate pool and the intracellular free Ca2+ activity in the rat kidney, were studied. The cAMP level in the kidney cortex homogenate was not changed after i.p. injection of aldosterone. Reliable changes in the content of inositol-phosphates in the kidney cell suspension was not revealed after aldosterone treatment. A short-term enhancement of the intracellular Ca2+ activity in the isolated distal convoluted and cortical collecting tubules under the influence of aldosterone, was revealed. The participation of the second messenger systems in the realisation of aldosterone effects in kidney and the role of Ca2+ in the mechanism of aldosterone action, are discussed.
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- author
- Svitasheva, N G LU ; Logvinenko, N S ; Solenov, E I and Ivanova, L N
- publishing date
- 1991-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aldosterone/pharmacology, Animals, Calcium/physiology, Cyclic AMP/physiology, Inositol Phosphates/physiology, Kidney/drug effects, Kidney Cortex/drug effects, Kidney Tubules, Collecting/drug effects, Kidney Tubules, Distal/drug effects, Male, Rats, Rats, Inbred Strains, Second Messenger Systems/drug effects
- in
- Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova
- volume
- 77
- issue
- 10
- pages
- 9 - 114
- publisher
- Izdatel'stvo Nauka
- external identifiers
-
- pmid:1666572
- scopus:0026357647
- ISSN
- 0015-329X
- language
- English
- LU publication?
- no
- id
- eb5a3fcd-3cb4-430b-bdae-b5e2f91d0b6e
- date added to LUP
- 2020-03-02 09:06:00
- date last changed
- 2024-01-02 06:59:15
@article{eb5a3fcd-3cb4-430b-bdae-b5e2f91d0b6e, abstract = {{<p>The effect of aldosterone on the cAMP level, the state of inositol-phosphate pool and the intracellular free Ca2+ activity in the rat kidney, were studied. The cAMP level in the kidney cortex homogenate was not changed after i.p. injection of aldosterone. Reliable changes in the content of inositol-phosphates in the kidney cell suspension was not revealed after aldosterone treatment. A short-term enhancement of the intracellular Ca2+ activity in the isolated distal convoluted and cortical collecting tubules under the influence of aldosterone, was revealed. The participation of the second messenger systems in the realisation of aldosterone effects in kidney and the role of Ca2+ in the mechanism of aldosterone action, are discussed.</p>}}, author = {{Svitasheva, N G and Logvinenko, N S and Solenov, E I and Ivanova, L N}}, issn = {{0015-329X}}, keywords = {{Aldosterone/pharmacology; Animals; Calcium/physiology; Cyclic AMP/physiology; Inositol Phosphates/physiology; Kidney/drug effects; Kidney Cortex/drug effects; Kidney Tubules, Collecting/drug effects; Kidney Tubules, Distal/drug effects; Male; Rats; Rats, Inbred Strains; Second Messenger Systems/drug effects}}, language = {{eng}}, number = {{10}}, pages = {{9--114}}, publisher = {{Izdatel'stvo Nauka}}, series = {{Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova}}, title = {{[The effect of aldosterone on the second messenger systems in the rat kidney]}}, volume = {{77}}, year = {{1991}}, }