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Treating obesity and heart failure : a how-to-manage guide from the European Association for the Study of obesity and the European Society of Hypertension working group on diabetes and metabolic risk factors

Antza, Christina ; Jordan, Jens ; McGowan, Barbara ; Ciudin, Andreea ; Filippi-Arriaga, Francesca ; Hoenemann, Jan Niklas ; Jelacovic, Anna ; Nilsson, Peter LU ; Tsioufis, Konstantinos and Doehner, Wolfram , et al. (2026) In Journal of Hypertension 44(6). p.938-947
Abstract

Obesity is a key contributor to heart failure, driving increased morbidity, mortality, and healthcare costs. This association is supported by multiple pathophysiological mechanisms and consistent epidemiological evidence, particularly not only in heart failure with preserved ejection fraction (HFpEF), but also in heart failure with reduced ejection fraction (HFrEF). Given the rising prevalence of both diseases, integrated management strategies are essential. This review outlines current management options in patients with heart failure and obesity, from lifestyle modification to pharmacological and surgical treatment, and explores emerging treatments aimed at mitigating this growing burden.

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Contribution to journal
publication status
published
subject
keywords
bariatric metabolic surgery, blood pressure, BMS, BP, gastric inhibitory polypeptide, GIP, GLP-1 RA, glucagon-like peptide-1 receptor antagonists, heart failure, heart failure hospitalization, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, HFpEF, HFrEF, HHF, hypertension, Kansas City Cardiomyopathy Questionnaire, KCCQ, left ventricular assist device, LVAD, obesity, SAT, SGLT2i, sodium-glucose cotransporter-2 inhibitors, subcutaneous adipose tissue, VAT, visceral adipose tissue
in
Journal of Hypertension
volume
44
issue
6
pages
938 - 947
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:105034317164
  • pmid:41818428
ISSN
0263-6352
DOI
10.1097/HJH.0000000000004285
language
English
LU publication?
yes
id
ed5fb81a-34bb-4ad2-ad2a-e57eab09fb4c
date added to LUP
2026-06-10 09:16:43
date last changed
2026-06-10 09:18:02
@article{ed5fb81a-34bb-4ad2-ad2a-e57eab09fb4c,
  abstract     = {{<p>Obesity is a key contributor to heart failure, driving increased morbidity, mortality, and healthcare costs. This association is supported by multiple pathophysiological mechanisms and consistent epidemiological evidence, particularly not only in heart failure with preserved ejection fraction (HFpEF), but also in heart failure with reduced ejection fraction (HFrEF). Given the rising prevalence of both diseases, integrated management strategies are essential. This review outlines current management options in patients with heart failure and obesity, from lifestyle modification to pharmacological and surgical treatment, and explores emerging treatments aimed at mitigating this growing burden.</p>}},
  author       = {{Antza, Christina and Jordan, Jens and McGowan, Barbara and Ciudin, Andreea and Filippi-Arriaga, Francesca and Hoenemann, Jan Niklas and Jelacovic, Anna and Nilsson, Peter and Tsioufis, Konstantinos and Doehner, Wolfram and Kotsis, Vasilios and Yumuk, Volkan}},
  issn         = {{0263-6352}},
  keywords     = {{bariatric metabolic surgery; blood pressure; BMS; BP; gastric inhibitory polypeptide; GIP; GLP-1 RA; glucagon-like peptide-1 receptor antagonists; heart failure; heart failure hospitalization; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction; HFpEF; HFrEF; HHF; hypertension; Kansas City Cardiomyopathy Questionnaire; KCCQ; left ventricular assist device; LVAD; obesity; SAT; SGLT2i; sodium-glucose cotransporter-2 inhibitors; subcutaneous adipose tissue; VAT; visceral adipose tissue}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{938--947}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{Treating obesity and heart failure : a how-to-manage guide from the European Association for the Study of obesity and the European Society of Hypertension working group on diabetes and metabolic risk factors}},
  url          = {{http://dx.doi.org/10.1097/HJH.0000000000004285}},
  doi          = {{10.1097/HJH.0000000000004285}},
  volume       = {{44}},
  year         = {{2026}},
}