The Peritoneal Membrane and Its Role in Peritoneal Dialysis
(2024) In Clinical Journal of the American Society of Nephrology 19(2). p.244-253- Abstract
A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on treatment influence dialysis prescription and outcomes, and dysfunction of the peritoneal membrane contributes to fluid overload and associated complications. In this review, we summarize the current knowledge about the structure, function, and pathophysiology of the peritoneal membrane with a focus on clinical implications for patient-centered care. We also discuss the molecular and genetic mechanisms of solute and water transport across the... (More)
A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on treatment influence dialysis prescription and outcomes, and dysfunction of the peritoneal membrane contributes to fluid overload and associated complications. In this review, we summarize the current knowledge about the structure, function, and pathophysiology of the peritoneal membrane with a focus on clinical implications for patient-centered care. We also discuss the molecular and genetic mechanisms of solute and water transport across the peritoneal membrane, including the role of aquaporin water channels in crystalloid versus colloid osmosis; why and how to assess membrane function using peritoneal equilibration tests; the etiologies of membrane dysfunction and their specific management; and the effect of genetic variation on membrane function and outcomes in patients treated with PD. This review also identifies the gaps in current knowledge and perspectives for future research to improve our understanding of the peritoneal membrane and, ultimately, the care of patients treated with PD.
(Less)
- author
- Morelle, Johann ; Lambie, Mark ; Öberg, Carl M. LU and Davies, Simon
- organization
- publishing date
- 2024-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- interstitial fibrosis, kidney failure, outcomes, peritoneal dialysis, peritoneal membrane, water channels, water transport
- in
- Clinical Journal of the American Society of Nephrology
- volume
- 19
- issue
- 2
- pages
- 10 pages
- publisher
- Amer Soc Nephrology
- external identifiers
-
- scopus:85190253683
- pmid:37616463
- ISSN
- 1555-9041
- DOI
- 10.2215/CJN.0000000000000282
- language
- English
- LU publication?
- yes
- id
- eda95338-3263-4a09-a1ac-d297448bda3c
- date added to LUP
- 2025-01-14 13:44:59
- date last changed
- 2025-07-16 17:54:48
@article{eda95338-3263-4a09-a1ac-d297448bda3c,
abstract = {{<p>A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on treatment influence dialysis prescription and outcomes, and dysfunction of the peritoneal membrane contributes to fluid overload and associated complications. In this review, we summarize the current knowledge about the structure, function, and pathophysiology of the peritoneal membrane with a focus on clinical implications for patient-centered care. We also discuss the molecular and genetic mechanisms of solute and water transport across the peritoneal membrane, including the role of aquaporin water channels in crystalloid versus colloid osmosis; why and how to assess membrane function using peritoneal equilibration tests; the etiologies of membrane dysfunction and their specific management; and the effect of genetic variation on membrane function and outcomes in patients treated with PD. This review also identifies the gaps in current knowledge and perspectives for future research to improve our understanding of the peritoneal membrane and, ultimately, the care of patients treated with PD.</p>}},
author = {{Morelle, Johann and Lambie, Mark and Öberg, Carl M. and Davies, Simon}},
issn = {{1555-9041}},
keywords = {{interstitial fibrosis; kidney failure; outcomes; peritoneal dialysis; peritoneal membrane; water channels; water transport}},
language = {{eng}},
number = {{2}},
pages = {{244--253}},
publisher = {{Amer Soc Nephrology}},
series = {{Clinical Journal of the American Society of Nephrology}},
title = {{The Peritoneal Membrane and Its Role in Peritoneal Dialysis}},
url = {{http://dx.doi.org/10.2215/CJN.0000000000000282}},
doi = {{10.2215/CJN.0000000000000282}},
volume = {{19}},
year = {{2024}},
}