Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Theocharis, Achilleas D ; Skandalis, Spyros S ; Neill, Thomas ; Multhaupt, Hinke A B ; Hubo, Mario ; Frey, Helena ; Gopal, Sandeep LU orcid ; Gomes, Angélica ; Afratis, Nikos and Lim, Hooi Ching LU , et al. (2015) In Biochimica et Biophysica Acta 1855(2). p.276-300
Abstract

Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that... (More)

Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
Breast Neoplasms/genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Molecular Targeted Therapy, Neovascularization, Pathologic/drug therapy, Proteoglycans/antagonists & inhibitors, Signal Transduction/genetics, Translational Medical Research, Tumor Microenvironment/genetics
in
Biochimica et Biophysica Acta
volume
1855
issue
2
pages
276 - 300
publisher
Elsevier
external identifiers
  • scopus:84927546643
  • pmid:25829250
ISSN
0006-3002
DOI
10.1016/j.bbcan.2015.03.006
language
English
LU publication?
no
additional info
Copyright © 2015 Elsevier B.V. All rights reserved.
id
ee56f64a-4a73-4fb7-8f39-6901c0e3a668
date added to LUP
2021-10-25 13:18:43
date last changed
2024-05-04 15:47:00
@article{ee56f64a-4a73-4fb7-8f39-6901c0e3a668,
  abstract     = {{<p>Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer. </p>}},
  author       = {{Theocharis, Achilleas D and Skandalis, Spyros S and Neill, Thomas and Multhaupt, Hinke A B and Hubo, Mario and Frey, Helena and Gopal, Sandeep and Gomes, Angélica and Afratis, Nikos and Lim, Hooi Ching and Couchman, John R and Filmus, Jorge and Sanderson, Ralph D and Schaefer, Liliana and Iozzo, Renato V and Karamanos, Nikos K}},
  issn         = {{0006-3002}},
  keywords     = {{Breast Neoplasms/genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Neovascularization, Pathologic/drug therapy; Proteoglycans/antagonists & inhibitors; Signal Transduction/genetics; Translational Medical Research; Tumor Microenvironment/genetics}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{276--300}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta}},
  title        = {{Insights into the key roles of proteoglycans in breast cancer biology and translational medicine}},
  url          = {{http://dx.doi.org/10.1016/j.bbcan.2015.03.006}},
  doi          = {{10.1016/j.bbcan.2015.03.006}},
  volume       = {{1855}},
  year         = {{2015}},
}