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Clinical Utility of Flow Cytometry for Detection of Anti-Jkb IgM in Acute Haemolytic Transfusion Reaction

Nagaharu, Keiki LU orcid ; Izumi, Takuya ; Maruyama, Mitsuko ; Sugimoto, Yuka ; Ohishi, Kohshi ; Tawara, Isao ; Usui, Eiji and Tamaki, Shigehisa (2024) In Internal Medicine 63(9). p.1273-1275
Abstract

Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jkb. We confirmed the presence of anti-Jkb IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Humans, Male, Aged, 80 and over, Immunoglobulin M/blood, Flow Cytometry, Transfusion Reaction/diagnosis, Erythrocyte Transfusion/adverse effects, Myelodysplastic Syndromes/immunology, Acute Disease
in
Internal Medicine
volume
63
issue
9
pages
1273 - 1275
publisher
Japanese Society of Internal Medicine
external identifiers
  • scopus:85191999061
  • pmid:37779057
ISSN
0918-2918
DOI
10.2169/internalmedicine.2639-23
language
English
LU publication?
no
id
f0700113-150d-4f72-8433-a31b6bbc5b94
date added to LUP
2026-01-07 11:08:32
date last changed
2026-01-08 04:01:13
@article{f0700113-150d-4f72-8433-a31b6bbc5b94,
  abstract     = {{<p>Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jkb. We confirmed the presence of anti-Jkb IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.</p>}},
  author       = {{Nagaharu, Keiki and Izumi, Takuya and Maruyama, Mitsuko and Sugimoto, Yuka and Ohishi, Kohshi and Tawara, Isao and Usui, Eiji and Tamaki, Shigehisa}},
  issn         = {{0918-2918}},
  keywords     = {{Humans; Male; Aged, 80 and over; Immunoglobulin M/blood; Flow Cytometry; Transfusion Reaction/diagnosis; Erythrocyte Transfusion/adverse effects; Myelodysplastic Syndromes/immunology; Acute Disease}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{9}},
  pages        = {{1273--1275}},
  publisher    = {{Japanese Society of Internal Medicine}},
  series       = {{Internal Medicine}},
  title        = {{Clinical Utility of Flow Cytometry for Detection of Anti-Jkb IgM in Acute Haemolytic Transfusion Reaction}},
  url          = {{http://dx.doi.org/10.2169/internalmedicine.2639-23}},
  doi          = {{10.2169/internalmedicine.2639-23}},
  volume       = {{63}},
  year         = {{2024}},
}