Cystatin C : a new marker of biocompatibility or a good marker for the redistribution of LMW proteins during hemodialysis?
(1988) In ASAIO Transactions 34(3). p.202-204- Abstract
The mechanism(s) behind the larger relative increase of Plasma beta 2 microglobulin (P-beta 2m) than that of Plasma albumin (P-alb) during Cuprophan hemodialysis is disputed. To elucidate this phenomenon P-alb, P-beta 2m (MW 11,800) and Plasma cystatin (P-cC; MW 13,000) an inhibitor of cystein proteinases, were determined before and after a Cuprophan or polysulphone hemodialysis (4-7 hr, QB 200 ml/min) in 30 stable regular dialysis treatment (RDT) patients. Body weight (BW) decreased by 2.5 +/- 1.4% (mean +/- SD). P-alb, P-beta 2m and P-cC increased by 11.4 +/- 14.8%, 15.4 +/- 11.5%, and 22.1 +/- 14.3%, respectively, during Cuprophan dialysis. The relative increase of P-cC was larger than that of P-beta 2m (P less than 0.05) and that of... (More)
The mechanism(s) behind the larger relative increase of Plasma beta 2 microglobulin (P-beta 2m) than that of Plasma albumin (P-alb) during Cuprophan hemodialysis is disputed. To elucidate this phenomenon P-alb, P-beta 2m (MW 11,800) and Plasma cystatin (P-cC; MW 13,000) an inhibitor of cystein proteinases, were determined before and after a Cuprophan or polysulphone hemodialysis (4-7 hr, QB 200 ml/min) in 30 stable regular dialysis treatment (RDT) patients. Body weight (BW) decreased by 2.5 +/- 1.4% (mean +/- SD). P-alb, P-beta 2m and P-cC increased by 11.4 +/- 14.8%, 15.4 +/- 11.5%, and 22.1 +/- 14.3%, respectively, during Cuprophan dialysis. The relative increase of P-cC was larger than that of P-beta 2m (P less than 0.05) and that of P-alb (P less than 0.02). During polysulphone dialysis BW decreased by 4.1 +/- 1.8%. P-alb, P-beta 2m, and P-cC increased almost equally by 28.1 +/- 18, 26.5 +/- 19.2, and 26.8 +/- 14.4%, respectively. These results are hard to interpret. Is the increase in P-cC a new marker of biocompatibility or does it reflect the true shift of low molecular weight (LMW) proteins between the interstitial and the plasma volume during hemodialysis better than P-beta 2m? In vitro studies indicate that small amounts of both Serum beta 2m (S-beta 2m) and Serum cystatin C (S-cC) are adsorbed to or sieved through the Cuprophan membrane, findings which render the kinetics of LMW proteins during hemodialysis still more complex.
(Less)
- author
- Thysell, Hans LU ; Grubb, Anders LU ; Lindholm, Tore ; Ljunggren, Lennart and Mårtensson, Lena
- organization
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biocompatible Materials, Blood Proteins, Body Weight, Cellulose/analogs & derivatives, Cystatin C, Cystatins, Humans, Membranes, Artificial, Polymers, Protease Inhibitors/blood, Renal Dialysis, Serum Albumin/analysis, Sulfones, beta 2-Microglobulin/analysis
- in
- ASAIO Transactions
- volume
- 34
- issue
- 3
- pages
- 202 - 204
- publisher
- Amercian Society of Artificial Internal Organs
- external identifiers
-
- pmid:3058174
- scopus:0023698888
- ISSN
- 0889-7190
- language
- English
- LU publication?
- yes
- id
- f1910299-69f2-47a5-b3a3-be4196e71532
- alternative location
- https://journals.lww.com/asaiojournal/Abstract/1988/07000/Cystatin_C__A_New_Marker_of_Biocompatibility_or_a.12.aspx
- date added to LUP
- 2021-10-27 08:45:21
- date last changed
- 2024-01-12 02:58:29
@article{f1910299-69f2-47a5-b3a3-be4196e71532, abstract = {{<p>The mechanism(s) behind the larger relative increase of Plasma beta 2 microglobulin (P-beta 2m) than that of Plasma albumin (P-alb) during Cuprophan hemodialysis is disputed. To elucidate this phenomenon P-alb, P-beta 2m (MW 11,800) and Plasma cystatin (P-cC; MW 13,000) an inhibitor of cystein proteinases, were determined before and after a Cuprophan or polysulphone hemodialysis (4-7 hr, QB 200 ml/min) in 30 stable regular dialysis treatment (RDT) patients. Body weight (BW) decreased by 2.5 +/- 1.4% (mean +/- SD). P-alb, P-beta 2m and P-cC increased by 11.4 +/- 14.8%, 15.4 +/- 11.5%, and 22.1 +/- 14.3%, respectively, during Cuprophan dialysis. The relative increase of P-cC was larger than that of P-beta 2m (P less than 0.05) and that of P-alb (P less than 0.02). During polysulphone dialysis BW decreased by 4.1 +/- 1.8%. P-alb, P-beta 2m, and P-cC increased almost equally by 28.1 +/- 18, 26.5 +/- 19.2, and 26.8 +/- 14.4%, respectively. These results are hard to interpret. Is the increase in P-cC a new marker of biocompatibility or does it reflect the true shift of low molecular weight (LMW) proteins between the interstitial and the plasma volume during hemodialysis better than P-beta 2m? In vitro studies indicate that small amounts of both Serum beta 2m (S-beta 2m) and Serum cystatin C (S-cC) are adsorbed to or sieved through the Cuprophan membrane, findings which render the kinetics of LMW proteins during hemodialysis still more complex.</p>}}, author = {{Thysell, Hans and Grubb, Anders and Lindholm, Tore and Ljunggren, Lennart and Mårtensson, Lena}}, issn = {{0889-7190}}, keywords = {{Biocompatible Materials; Blood Proteins; Body Weight; Cellulose/analogs & derivatives; Cystatin C; Cystatins; Humans; Membranes, Artificial; Polymers; Protease Inhibitors/blood; Renal Dialysis; Serum Albumin/analysis; Sulfones; beta 2-Microglobulin/analysis}}, language = {{eng}}, number = {{3}}, pages = {{202--204}}, publisher = {{Amercian Society of Artificial Internal Organs}}, series = {{ASAIO Transactions}}, title = {{Cystatin C : a new marker of biocompatibility or a good marker for the redistribution of LMW proteins during hemodialysis?}}, url = {{https://journals.lww.com/asaiojournal/Abstract/1988/07000/Cystatin_C__A_New_Marker_of_Biocompatibility_or_a.12.aspx}}, volume = {{34}}, year = {{1988}}, }