High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma
(2020) In Journal of Cancer 11(23). p.6760-6767- Abstract
Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could... (More)
Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.
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- author
- Ke, Hengning ; Yang, Yv Ying ; Lin, Yuan ; Liu, Li ; Sun, Jianmin LU and Massoumi, Ramin LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CD34, Squamous cell carcinoma, UV-B, α6-integrin
- in
- Journal of Cancer
- volume
- 11
- issue
- 23
- pages
- 8 pages
- publisher
- Ivyspring International Publisher
- external identifiers
-
- scopus:85094587114
- pmid:33123267
- ISSN
- 1837-9664
- DOI
- 10.7150/jca.45819
- language
- English
- LU publication?
- yes
- id
- f2732f02-344b-4109-8966-4acb6a62e542
- date added to LUP
- 2020-11-17 10:21:58
- date last changed
- 2024-04-03 18:08:05
@article{f2732f02-344b-4109-8966-4acb6a62e542, abstract = {{<p>Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34<sup>low</sup>α6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.</p>}}, author = {{Ke, Hengning and Yang, Yv Ying and Lin, Yuan and Liu, Li and Sun, Jianmin and Massoumi, Ramin}}, issn = {{1837-9664}}, keywords = {{CD34; Squamous cell carcinoma; UV-B; α6-integrin}}, language = {{eng}}, number = {{23}}, pages = {{6760--6767}}, publisher = {{Ivyspring International Publisher}}, series = {{Journal of Cancer}}, title = {{High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma}}, url = {{http://dx.doi.org/10.7150/jca.45819}}, doi = {{10.7150/jca.45819}}, volume = {{11}}, year = {{2020}}, }