The epidemiology and outcomes of acute kidney injury following orthopaedic procedures : A retrospective cohort study
(2024) In Acta Anaesthesiologica Scandinavica 68(1). p.26-34- Abstract
Background: Acute kidney injury (AKI) is a serious complication following major surgery. This study examined the incidence and risk factors of AKI following orthopaedic surgeries in an Icelandic cohort, as well as the association between AKI and patient- and surgery-related factors. Methods: This retrospective cohort study comprised all patients 18 years and older who underwent orthopaedic surgeries at Landspitali – The National University Hospital in the years 2006–2018 with available serum creatinine (SCr) measurements adjacent to the surgery to stage AKI. AKI was defined according to SCr portion of the KDIGO criteria. Logistic regression was used to identify patient- and surgical factors related to progression of AKI and... (More)
Background: Acute kidney injury (AKI) is a serious complication following major surgery. This study examined the incidence and risk factors of AKI following orthopaedic surgeries in an Icelandic cohort, as well as the association between AKI and patient- and surgery-related factors. Methods: This retrospective cohort study comprised all patients 18 years and older who underwent orthopaedic surgeries at Landspitali – The National University Hospital in the years 2006–2018 with available serum creatinine (SCr) measurements adjacent to the surgery to stage AKI. AKI was defined according to SCr portion of the KDIGO criteria. Logistic regression was used to identify patient- and surgical factors related to progression of AKI and Poisson-regression was used to explore changes in incidence. Results: A total of 222 cases of AKI following 3208 surgeries (6.9%) were identified in the study period with a rise in the incidence by about 17% per year. Higher age (odds ratio (OR), 1.02, 95% confidence interval (CI), 1.01–1.04 per year) and underlying reduction in kidney function (OR 1.93 (1.30–2.81), 3.24 (2.08–4.96) and 4.08 (2.35–6.96) for estimated glomerular filtration rate (eGFR) of 30–59, 15–29 and <15 mL/min/1.73 m2 compared with eGFR >60 mL/min/1.73 m2) were associated with higher risk of AKI, but female sex was associated with decreased odds (OR = 0.73; 95% CI, 0.54–0.98). After correcting for age, sex, preoperative kidney function, emergency surgery and underlying comorbidities and frailty, there was an increased risk of long-term mortality in patients with AKI (HR 1.41, 95% CI 1.08–1.85), and patients who developed AKI also had accelerated progression of chronic kidney disease compared with patients who did not develop AKI. Conclusions: The incidence of AKI following orthopaedic surgeries is increasing and is associated with adverse outcomes. It is important that elderly individuals and patients who have reduced kidney function receive adequate monitoring and surveillance in the perioperative period.
(Less)
- author
- Thorsdottir, Helga ; Long, Thorir E. LU ; Palsson, Runolfur and Sigurdsson, Martin I.
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute kidney injury, arthroplasty, chronic kidney insufficiency, hip replacement, knee replacement
- in
- Acta Anaesthesiologica Scandinavica
- volume
- 68
- issue
- 1
- pages
- 26 - 34
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85171574826
- pmid:37726880
- ISSN
- 0001-5172
- DOI
- 10.1111/aas.14332
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2023 Acta Anaesthesiologica Scandinavica Foundation.
- id
- f37bf341-1fce-41c5-9c11-b2aebe110cee
- date added to LUP
- 2023-12-21 10:59:44
- date last changed
- 2024-11-17 18:28:53
@article{f37bf341-1fce-41c5-9c11-b2aebe110cee,
abstract = {{<p>Background: Acute kidney injury (AKI) is a serious complication following major surgery. This study examined the incidence and risk factors of AKI following orthopaedic surgeries in an Icelandic cohort, as well as the association between AKI and patient- and surgery-related factors. Methods: This retrospective cohort study comprised all patients 18 years and older who underwent orthopaedic surgeries at Landspitali – The National University Hospital in the years 2006–2018 with available serum creatinine (SCr) measurements adjacent to the surgery to stage AKI. AKI was defined according to SCr portion of the KDIGO criteria. Logistic regression was used to identify patient- and surgical factors related to progression of AKI and Poisson-regression was used to explore changes in incidence. Results: A total of 222 cases of AKI following 3208 surgeries (6.9%) were identified in the study period with a rise in the incidence by about 17% per year. Higher age (odds ratio (OR), 1.02, 95% confidence interval (CI), 1.01–1.04 per year) and underlying reduction in kidney function (OR 1.93 (1.30–2.81), 3.24 (2.08–4.96) and 4.08 (2.35–6.96) for estimated glomerular filtration rate (eGFR) of 30–59, 15–29 and <15 mL/min/1.73 m<sup>2</sup> compared with eGFR >60 mL/min/1.73 m<sup>2</sup>) were associated with higher risk of AKI, but female sex was associated with decreased odds (OR = 0.73; 95% CI, 0.54–0.98). After correcting for age, sex, preoperative kidney function, emergency surgery and underlying comorbidities and frailty, there was an increased risk of long-term mortality in patients with AKI (HR 1.41, 95% CI 1.08–1.85), and patients who developed AKI also had accelerated progression of chronic kidney disease compared with patients who did not develop AKI. Conclusions: The incidence of AKI following orthopaedic surgeries is increasing and is associated with adverse outcomes. It is important that elderly individuals and patients who have reduced kidney function receive adequate monitoring and surveillance in the perioperative period.</p>}},
author = {{Thorsdottir, Helga and Long, Thorir E. and Palsson, Runolfur and Sigurdsson, Martin I.}},
issn = {{0001-5172}},
keywords = {{acute kidney injury; arthroplasty; chronic kidney insufficiency; hip replacement; knee replacement}},
language = {{eng}},
number = {{1}},
pages = {{26--34}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Anaesthesiologica Scandinavica}},
title = {{The epidemiology and outcomes of acute kidney injury following orthopaedic procedures : A retrospective cohort study}},
url = {{http://dx.doi.org/10.1111/aas.14332}},
doi = {{10.1111/aas.14332}},
volume = {{68}},
year = {{2024}},
}