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Unveiling the hippocampal subfield changes across the Alzheimer’s disease continuum : a systematic review of neuroimaging studies

Zilioli, Alessandro ; Pancaldi, Beatrice ; Baumeister, Hannah ; Busi, Gabriele ; Misirocchi, Francesco ; Mutti, Carlotta ; Florindo, Irene ; Morelli, Nicola ; Mohanty, Rosaleena and Berron, David LU , et al. (2024) In Brain Imaging and Behavior 19(1). p.253-267
Abstract

Studies exploring the hippocampal subfield atrophy in Alzheimer’s disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with... (More)

Studies exploring the hippocampal subfield atrophy in Alzheimer’s disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with disease progression. Consistent findings revealed atrophy in the subiculum and presubiculum, along with a potential increase in volume in the cornu ammonis (CA) among the cognitively unimpaired group, a feature not observed in patients experiencing subjective cognitive decline. Atrophy in the subiculum, presubiculum, CA 1–4, and the dentate gyrus characterized the mild cognitive impairment stage, with a more pronounced severity in the progression to dementia.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer’s disease continuum, Hippocampal subfields, Hippocampal volume and surface
in
Brain Imaging and Behavior
volume
19
issue
1
pages
15 pages
publisher
Springer
external identifiers
  • scopus:85206997928
  • pmid:39443362
ISSN
1931-7557
DOI
10.1007/s11682-024-00952-0
language
English
LU publication?
yes
id
f4181e42-cef9-469a-af15-c2aca26bb67b
date added to LUP
2025-01-02 15:32:12
date last changed
2025-07-18 21:34:24
@article{f4181e42-cef9-469a-af15-c2aca26bb67b,
  abstract     = {{<p>Studies exploring the hippocampal subfield atrophy in Alzheimer’s disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with disease progression. Consistent findings revealed atrophy in the subiculum and presubiculum, along with a potential increase in volume in the cornu ammonis (CA) among the cognitively unimpaired group, a feature not observed in patients experiencing subjective cognitive decline. Atrophy in the subiculum, presubiculum, CA 1–4, and the dentate gyrus characterized the mild cognitive impairment stage, with a more pronounced severity in the progression to dementia.</p>}},
  author       = {{Zilioli, Alessandro and Pancaldi, Beatrice and Baumeister, Hannah and Busi, Gabriele and Misirocchi, Francesco and Mutti, Carlotta and Florindo, Irene and Morelli, Nicola and Mohanty, Rosaleena and Berron, David and Westman, Eric and Spallazzi, Marco}},
  issn         = {{1931-7557}},
  keywords     = {{Alzheimer’s disease continuum; Hippocampal subfields; Hippocampal volume and surface}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{253--267}},
  publisher    = {{Springer}},
  series       = {{Brain Imaging and Behavior}},
  title        = {{Unveiling the hippocampal subfield changes across the Alzheimer’s disease continuum : a systematic review of neuroimaging studies}},
  url          = {{http://dx.doi.org/10.1007/s11682-024-00952-0}},
  doi          = {{10.1007/s11682-024-00952-0}},
  volume       = {{19}},
  year         = {{2024}},
}